Elucidation and application of histone-mediated anti-viral innate immune activation mechanisms.

本研究旨在阐明组蛋白h2b诱导的先天免疫激活机制和dna诱导的先天免疫信号传导机制。先前，我们发现组蛋白H2B参与了dna介导的先天免疫激活。在本研究中，我们发现组蛋白H2B不仅参与DNA病毒的复制，还通过细胞质DNA识别参与RNA病毒的复制。此外，我们利用siRNA文库对dna介导的先天免疫信号分子进行了筛选。因此，我们发现了一些参与先天免疫信号的分子。

The aim of this research is to clarify the mechanisms of histone H2B-induced innate immune activation and the mechanisms of DNA-induced innate immune signaling. Previously, we identified that histone H2B is involved in dsDNA-mediated innate immune activation. In this research, we showed that histone H2B involves in not only DNA virus but also RNA virus replication through cytosolic DNA recognition. In addition, we performed screening of DNA-mediated innate immune signaling molecules using siRNA library. As a result, we showed that some molecules involved in innate immune signaling.