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The role for Laptm5 in the down-modulation of pre-B cell receptor

The role for Laptm5 in the down-modulation of pre-B cell receptor
Laptm5 在前 B 细胞受体下调中的作用
批准号:
23790530
负责人:
KAWANO Youhei
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
翻译
B细胞前受体(Pre-B cell receptor, pre-BCR)的表达在正常的B细胞发育过程中必须受到严格的调控,而其失调与B系细胞的异常有关,包括白血病的发生。然而,尽管目前提出了pre-BCR组分的转录沉默,但对pre-BCR下调的机制仍不明确。在本文中,我们发现溶酶体膜蛋白Laptm5通过自主bcr前信号上调,随后通过促进其在溶酶体中的降解下调bcr前信号。值得注意的是,这一发现表明,在蛋白质水平上,通过调控Laptm5,存在另一种bcr前下调机制。
英文摘要
Pre-B cell receptor (pre-BCR) expression has to be strictly regulated for normal B cell development, and its dysregulation is associated with anomalies of B-lineage cells, including leukemogenesis. However, it remained elusive on the mechanism underlying pre-BCR down-modulation although transcriptional silencing of pre-BCR component is currently proposed. In this paper, we found that a lysosomal membrane protein, Laptm5 is up-regulated via autonomous pre-BCR signaling, followed by pre-BCR down-modulation by promoting its degradation in lysosomes. Of note, this finding suggests there is another mechanism of pre-BCR down-modulation at the protein level through the regulation of Laptm5.
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DOI: 10.1128/mcb.00531-12
发表时间: 2012-11-01
期刊: MOLECULAR AND CELLULAR BIOLOGY
影响因子: 5.3
作者: [Kawano, Yohei, Ouchida, Rika, Karasuyama, Hajime]
通讯作者: Karasuyama, Hajime
LAPTM5 down-modulates pre-B cell receptor in an autophagy-independent manner
LAPTM5 以不依赖自噬的方式下调前 B 细胞受体
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Ito, T., Kitajima, M., Tumes, J. D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., and Nakayama, T., 河野洋平]
通讯作者: 河野洋平
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Honda K, Atarashi K, Nishio J., Yohei Kawano]
通讯作者: Yohei Kawano
Laptm5 down-modulates pre-B cell receptor in anautophagy-independent manner
Laptm5 以不依赖自噬的方式下调前 B 细胞受体
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Kawano, Y., Ouchida, R., O-Wang, J., Yoshikawa, S., Yamamoto, M., Kitamura, D., Karasuyama, H.]
通讯作者: H.
Tne regulation mechanism of pre-B cell receptor expression and pre-B acute lymphoblastic lymphomagenesis
  • 批准号:
    21790461
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.83万
  • 财政年份:
    2009
  • 负责人:
    KAWANO Youhei
  • 依托单位:
海外基金