Tne regulation mechanism of pre-B cell receptor expression and pre-B acute lymphoblastic lymphomagenesis

前B细胞受体表达与前B急性淋巴细胞淋巴瘤发生的调控机制

• 批准号: 21790461
• 负责人: KAWANO Youhei
• 金额: $ 2.83万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790461/
• 关键词: プレB細胞; pre-BCR; リソソーム; BCR

Pre-BCR is a constitutively active receptor, transienly expressed on only pre-B cells, and its abberant expression cause pre-B acute lymphoblastic lymphoma. We study the regulation mechanism of the pre-BCR expression, and identified a molecule localized in lysosome that is involved in the degradation of pre-BCR.

前BCR是一种组成型活性受体，仅在前B细胞上瞬时表达，其异常表达导致前B急性淋巴母细胞性淋巴瘤。我们研究了前BCR表达的调控机制，并鉴定了位于溶酶体中的参与前BCR降解的分子。

项目成果

IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen

• DOI: 10.1016/j.bbrc.2010.10.098
• 发表时间: 2010-11-26
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Ishikawa, Ryosuke;Tsujimura, Yusuke;Karasuyama, Hajime
• 通讯作者: Karasuyama, Hajime

Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks

• DOI: 10.1172/jci42680
• 发表时间: 2010-08-01
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Wada, Takeshi;Ishiwata, Kenji;Karasuyama, Hajime
• 通讯作者: Karasuyama, Hajime

A novel mechanism for the autonomous termination of pre-Bcell receptor expression through BLNK-mediated induction of LAPTM5.

通过 BLNK 介导的 LAPTM5 诱导自主终止前 B 细胞受体表达的新机制。

• 发表时间: 2010
• 作者: Kawano Y.;Ouchida R;O-Wang Jiyang;Yoshikawa S;Yamamoto M.;Kitamura D.;Karasuyama H.
• 通讯作者: Karasuyama H.

Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells

• DOI: 10.1189/jlb.0609400
• 发表时间: 2009-12-01
• 期刊: JOURNAL OF LEUKOCYTE BIOLOGY
• 影响因子: 5.5
• 作者: Ugajin, Tsukasa;Kojima, Toshiyuki;Karasuyama, Hajime
• 通讯作者: Karasuyama, Hajime