Analysis of the mechanisms of allopurinol-induced severe cutaneous adverse reactions

别嘌呤醇致严重皮肤不良反应的机制分析

• 批准号: 23790611
• 负责人: SUGIYAMA Emiko
• 金额: $ 2.91万
• 依托单位: National Institute of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790611/
• 关键词: 医薬品副作用; 反応性代謝物; アロプリノール; 重症薬疹; 副作用

To investigate whether allopurinol or phenytoin generate drug-protein adduct, each drugs were incubated with various human liver tissues. As a result, it is suggested that cytochrome P450 activities and the concentration of glutathione in cells are of importance for generation of drug-protein adduct formation with phenytoin. In addition, although it have not been reported that P450 activities are involved in the allopurinol metabolism, the result of this study suggested that P450 activities played a role in generation of the drug-protein adduct.

为了研究别嘌呤醇或苯妥英是否产生药物-蛋白加合物，将每种药物与各种人肝组织孵育。结果表明，细胞内细胞色素P450活性和谷胱甘肽浓度对苯妥英钠与药物蛋白加合物的形成具有重要意义。此外，尽管尚未有P450活性参与别嘌呤醇代谢的报道，但本研究结果表明P450活性在药物-蛋白加合物的产生中发挥了作用。

项目成果

日本人における抗てんかん薬誘因性SJS/TEN とHLA タイプとの相関解析

日本人抗癫痫药物诱发的SJS/TEN与HLA型的相关性分析

• 发表时间: 2013
• 作者: 杉山永見子;鹿庭なほ子;高橋幸利;古谷 博和;村松正明;木下茂;莚田泰誠;黒瀬光 一;頭金正博;前川京子;矢上晶子;安部正 通;外園千恵;上田真由美;池田浩子;池澤 善郎;日本データサイエンスコンソーシアム;松永佳世子;相原道子;斎藤嘉朗
• 通讯作者: 斎藤嘉朗