Morphological analysis of limbic modulation of descending pain inhibitory system

下行疼痛抑制系统边缘调节的形态学分析

• 批准号: 23790643
• 负责人: OKA Tatsuro
• 金额: $ 2.75万
• 依托单位: Shimane University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790643/
• 关键词: 下行性疼痛抑制系; 中心灰白質; 辺縁系; 視床下部; 扁桃体; 大縫線核; 神経回路; ラット

To understand how limbic structures influence descending antinociceptive system, we examined whether hypothalamic and amygdaloid terminals make synaptic contact with rostral ventromedial medulla (RVM)-projecting neurons in the periaqueductal gray (PAG). As a result, prominent overlapping distribution of the ventromedial hypothalamic axons and RVM-projecting neurons was observed in the lateral/dorsomedial part of the PAG. Furthermore, electron microscopic observation revealed that ventromedial hypothalamic terminals made asymmetrical synaptic contactswith RVM-projecting PAG neurons. We further demonstrated that most of the RVM-projecting PAG neurons are positive for vesicular glutamate transporter 2 mRNA, suggesting that these neurons are glutamatergic.

为了了解边缘系统的结构如何影响下行的抗伤害性感受系统，我们研究了下丘脑和杏仁核终末是否与中脑导水管周围灰质（PAG）的延髓头端腹内侧（RVM）投射神经元形成突触联系。结果，下丘脑腹内侧轴突和RVM投射神经元的突出重叠分布在PAG的外侧/背内侧部分。电镜观察显示，下丘脑腹内侧终末与投射于右心室的PAG神经元形成不对称的突触联系。我们进一步证明，大多数的RVM投射PAG神经元是积极的囊泡谷氨酸转运体2 mRNA，这表明这些神经元是谷氨酸能。

项目成果

Glutamatergic neurons in the lateral periaqueductal gray innervate neurokinin-1 receptor-expressing neurons in the ventrolateral medulla of the rat

• DOI: 10.1016/j.neures.2012.08.001
• 发表时间: 2011-09
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: T. Oka;S. Yokota;T. Tsumori;Jian-guo Niu;Y. Yasui

Glutamatergic Kolliker-Fuse nucleus neurons innervate hypoglossal motoneurons whose axons form the medial (protruder)branch of the hypoglossal nerve in therat

谷氨酸科利克融合核神经元支配舌下运动神经元，其轴突形成大鼠舌下神经的内侧（突出）分支

• DOI: 10.1016/j.brainres.2011.06.025
• 发表时间: 2011
• 期刊: Brain Research
• 影响因子: 2.9
• 作者: Yokota S;Niu JG;Tsumori T;Oka T,Yasui Y
• 通讯作者: Oka T,Yasui Y

Glutamatergic neurons in the lateral part of the periaqueductal gray innervate neurokinin-1 receptor-expressing neurons in the ventrolateral medulla of the rat

导水管周围灰色外侧部分的谷氨酸能神经元支配大鼠腹外侧延髓中表达神经激肽-1受体的神经元

• 发表时间: 2011
• 作者: T. Tsumori;T. Oka;JG. Niu;Y. Yasui;岡 達郎
• 通讯作者: 岡 達郎

Pancreatic islets cells receive axon terminals from melanocortin-4 receptor-expressing nodose ganglion cells in the mouse

小鼠胰岛细胞接收来自表达黑皮质素 4 受体的结状神经节细胞的轴突末端

• 发表时间: 2013
• 作者: 津森登志子;岡 達郎;横田茂文;安井幸彦
• 通讯作者: 安井幸彦

Synaptic organization between melanocortin-4 receptor-expressing neurons in the dorsal motor nucleus of the vagus nerve and enteric ganglia neurons in the mouse

小鼠迷走神经背运动核中表达黑皮质素 4 受体的神经元与肠神经节神经元之间的突触组织

• 发表时间: 2011
• 作者: 津森登志子;岡 達郎;牛 建国;安井幸彦
• 通讯作者: 安井幸彦