Analysis of gene expression regulation of intelectin-1 in malignant pleural mesothelioma

本研究发现，intelectin-1在恶性胸膜间皮瘤或胃肠化生中有表达，而在正常胸膜和正常胃中无表达。然而，其他病变标志物的表达并不相似。因此，肠上皮化生和MPM中intelectin-1的表达可能受不同的基因调控机制的相互调控。MPM中intelectin-1的启动子和增强子分别位于转录起始点的-56~6个核苷酸和263~293个核苷酸之间。增强子区域的数据库分析表明，OCT和SOX转录因子可能是MPM中intelectin-1的转录因子。

In this study, we found that intelectin-1 was expressed in malignant pleural mesothelioma (MPM) or intestinal metaplasia in stomach, but not in normal pleura and normal stomach. However, expression of other lesion markers was not similar. Therefore, intelectin-1 expression in MPM and intestinal metaplasia may be regulated by different gene regulatory mechanisms each other. The promoter and enhancer of intelectin-1 in MPM located on a region from -56 to +6 nucleotides including a TATA box element and from +263 to +293 nucleotides, respectively, for the transcription start site. Database analysis of the enhancer region suggested that Oct and Sox transcriptional factors might function as transcriptional factors of intelectin-1 in MPM.