Association between polyunsaturated fatty acids and renal function assessed by serum cystatin C in urban and rural Japanese population

在神户市普通人群中，调整了年龄、性别和其他经典心血管危险因素后，超敏C反应蛋白(hs-CRP)与心踝血管指数(CAVI)呈显著正相关。这一结果也表明，炎症与动脉粥样硬化有关，而动脉粥样硬化与普通人群中的肾功能障碍有关。然后，我们在佐山市的普通人群中调查了肾功能与n-3多不饱和脂肪酸之间的关系，如EPA和DHA，这些多不饱和脂肪酸已知具有抗炎作用。EPA和DHA与Cystatin C估计的肾小球滤过率呈正相关。因此，摄取鱼类可以预防一般人群的肾功能损害。

Among general population in Kobe city, high-sensitivity C-reactive protein (hs-CRP) showed significant positive association with cardio-ankle vascular index (CAVI) after adjustment for age, sex and other classical cardiovascular risk factors. This result suggests that inflammation is associated with atherosclerosis which relates to renal dysfunction in general population, either. Then we investigated the association between renal function and n-3 polyunsaturated fatty acids such as EPA and DHA which are known to have anti-inflammation effects, among general population in Sasayama city. EPA and DHA showed positive relationship with glomerular filtration rate estimated by cystatin C. Thus fish intake could prevent renal dysfunction in general population.