Elevated Serum N-acetyl-s-D-Glucosaminidase Activity is a Predictor of 28-Year Mortality in a Population of Community-dwelling Japanese

血清 N-乙酰-s-D-氨基葡萄糖苷酶活性升高是居住在社区的日本人 28 年死亡率的预测因子

• 批准号: 23790713
• 负责人: YOSHIKAWA Kuniko
• 金额: $ 2.75万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790713/
• 关键词: 健康診断; 疫学; アセチルグルコサミニダーゼ; 死亡率; 前向き研究; 社会医学

Elevated serum N-acetyl-s-D-Glucosaminidase (NAG) activity is related to various cardiovascular risk factors and is a predictor of incident hypertension. Urinary but not serum NAG activity was an important prognostic marker in renal diseases. We measured serum NAG activities in 1,080 apparently healthy subjects (aged over 20 years) in 1982. Importantly, we reported 17 years ago that high serum NAG activity was a predictor of future development of hypertension in a general population. We hypothesized that elevated serum NAG activity would be a predictor of cerebro-cardiovascular death in community-based cohort study. Accordingly, we examined whether the serum NAG activity would predict 28-year cerebro-cardiovascular and all-cause deaths in the same population. The hazard ratio of all-cause death in the highest quartile of serum NAG (?14.0 IU/L) vs. the lowest quartile after adjustment for confounding factors was 1.35 (95% CI,1.02-1.83). On the other hand, no significant associatins were found between NAG activities and cardiovascular mortality. In conclusion, the present study suggests that the serum NAG activity is an independent predictor of all-cause mortality in a general population.

血清N-乙酰-S-D-氨基葡萄糖苷酶(NAG)活性升高与多种心血管危险因素有关，是高血压发病的预测因子。尿NAG活性是肾脏疾病的重要预后指标，而不是血清NAG活性。1982年，我们测定了1080名表面健康的老年人(20岁以上)的血清NAG活性。重要的是，我们在17年前就报道过，在普通人群中，高水平的血清NAG活性是高血压未来发展的预测指标。我们假设，在基于社区的队列研究中，血清NAG活性升高将是脑血管疾病死亡的预测因子。因此，我们检查了血清NAG活性是否可以预测同一人群28年的心脑血管疾病和全因死亡。调整混杂因素后，血清NAG最高四分位数(？14.0IU/L)与最低四分位数的全因死亡风险比为1.35(95%CI，1.02~1.83)。另一方面，在NAG活性和心血管死亡率之间没有发现显著的关联。综上所述，本研究提示血清NAG活性是普通人群全因死亡率的独立预测因子。

项目成果

New computer model for prediction of individual 10-year mortality on the basis of conventionalatherosclerotic risk factors.

基于传统动脉粥样硬化危险因素预测个人 10 年死亡率的新计算机模型。

• DOI: 10.1016/j.atherosclerosis.2012.12.023
• 发表时间: 2013
• 期刊: Atherosclerosis.
• 作者: Ogata K;MiyamotoT;Adachi H;Hirai Y;Enomoto M;Fukami A;Yokoi K;Kasahara A;Tsukagawa E;Yoshimura A;Obuchi A;Nakamura S;Imaizumi T.
• 通讯作者: Imaizumi T.

Elevated Serum N-acetyl-ß-D-Glucosaminidase Activity is a Predictor of 28-Year Mortality in a Population of Community-dwelling Japanese-The Tanushimaru Study -

血清 N-乙酰-β-D-氨基葡萄糖苷酶活性升高是居住在社区的日本人 28 年死亡率的预测因子 - Tanushimaru 研究 -

• 发表时间: 2013
• 期刊: Journal of the American Geriatrics Society
• 影响因子: 6.3
• 作者: Kasahara A;Adachi H;Hirai Y;Enomoto M;Fukami A;Yoshikawa K;Esaki E;Yokoi K;Ogata K;Tsukagawa E;Obuchi A;Yoshimura A;Nakamura S;Imaizumi T.;Kuniko Yoshikawa
• 通讯作者: Kuniko Yoshikawa

LDL-C/HDL-C Ratio Predicts Carotid Intima-Media Thickness Progression Better Than HDL-C or LDL-C Alone.

• DOI: 10.1155/2011/549137
• 发表时间: 2011
• 期刊: Journal of lipids
• 影响因子: 5.3
• 作者: Enomoto M;Adachi H;Hirai Y;Fukami A;Satoh A;Otsuka M;Kumagae S;Nanjo Y;Yoshikawa K;Esaki E;Kumagai E;Ogata K;Kasahara A;Tsukagawa E;Yokoi K;Ohbu-Murayama K;Imaizumi T
• 通讯作者: Imaizumi T

Serum Hepatocyte Growth Factor and Cancer Mortality in an Apparently Healthy Japanese Population

• DOI: 10.2188/jea.je20110121
• 发表时间: 2012-09-01
• 期刊: JOURNAL OF EPIDEMIOLOGY
• 影响因子: 4.7
• 作者: Otsuka, Maki;Adachi, Hisashi;Imaizumi, Tsutomu
• 通讯作者: Imaizumi, Tsutomu

High serum N-acetyl- β -d-glucosaminidase activity is predictor of 28-year mortality in a population of community-dwelling Japanease ? the Tanushimaru study.

Tanushimaru 研究显示，高血清 N-乙酰基-β-d-氨基葡萄糖苷酶活性是日本社区居民 28 年死亡率的预测因子。

• DOI: 10.1111/jgs.12083
• 发表时间: 2013
• 期刊: J Am Geriatr Soc.
• 作者: Yoshikawa K;Adachi H;Hirai Y;Enomoto M;Fukami A;Ogata K;Tsukagawa E;Kasahara A;Yokoi K;Okina N;Obuchi A;Yoshimura A;Nakamura S;Imaizumi T.
• 通讯作者: Imaizumi T.