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Development of simultaneous micro analysis method for muscle relaxants in biological samples by UPLC-MS/MS

Development of simultaneous micro analysis method for muscle relaxants in biological samples by UPLC-MS/MS
UPLC-MS/MS 开发生物样品中肌肉松弛剂同步微量分析方法
批准号：
23790732
负责人：
OGAWA Tadashi
金额：
$2.83万
依托单位：
Aichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790732/
关键词：
中枢性筋弛緩薬末梢性筋弛緩薬UPLC-MS/MS法中毒筋弛緩薬UPLC-MS-MSESI-APCI同時イオン化モード筋弛緩剤

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中文摘要
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英文摘要
In this study, rapid and sensitive methods for simultaneous analysis of muscle relaxants by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) were developed.Simultaneous analysis of central-acting muscle relaxants by UPLC-MS/MS has been realized by the capability of our instrument for simultaneous selected reaction monitoring of the target compounds in both positive and negative ionization modes. On the other hand, quantification of peripheral non-depolarizing muscle relaxants was difficult by LC-MS/MS with ESI (Electrospray ionization) mode. However, the developed simultaneous analysis method of non-depolarizing muscle relaxants in whole blood by UPLC-MS/MS with ESI-APCI (Atmospheric pressure chemical ionization) mix ionization mode in this study showed better quantitativity.
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会议论文
UPLC-MS/MSを用いた血漿中筋弛緩剤の一斉分析
使用 UPLC-MS/MS 同时分析血浆中的肌肉松弛剂
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Tadashi Ogawa, Kenjiro Ito, Hideki Hattori, Jun Ueyama, Masae Iwai, Kenya Iwakura, Akira Ishii, Osamu Suzuki, Hiroshi Seno, 小川匡之,服部秀樹,金子理奈,伊藤健次郎,岩井雅枝,星野伸忠,有信哲哉,石井晃,鈴木修,妹尾洋]
通讯作者： 小川匡之,服部秀樹,金子理奈,伊藤健次郎,岩井雅枝,星野伸忠,有信哲哉,石井晃,鈴木修,妹尾洋
Simultaneous analysis of peripheral muscle relaxants in whole blood by ultra-performance liquid chromatography tandem mass spectrometry
超高效液相色谱串联质谱法同时分析全血中的外周肌松弛剂
DOI： --
发表时间： 2012
期刊：
影响因子： --
作者： [Fukudo S, Machida T, Endo Y, Shoji T, Kano M, Kanazawa M., Tadashi Ogawa]
通讯作者： Tadashi Ogawa
SIMPLE AND RAPID QUANTITATION OF 21 BILE ACIDS IN RAT SERUM AND LIVER BY UPLC-MS-MS: EFFECT OF HIGH FAT DIET ON GLYCINE CONJUGATES OF RAT BILE ACIDS
DOI： 10.18999/nagjms.75.1-2.57
发表时间： 2013-02
期刊： Nagoya Journal of Medical Science
影响因子： 0.9
作者： [Yudai Suzuki;R. Kaneko;Mina Nomura;Hisao Naito;K. Kitamori;T. Nakajima;Tadashi Ogawa;H. Hattori;H. Seno;A. Ishii]
通讯作者： Yudai Suzuki;R. Kaneko;Mina Nomura;Hisao Naito;K. Kitamori;T. Nakajima;Tadashi Ogawa;H. Hattori;H. Seno;A. Ishii
High-throughput and simultaneous analysis of eight central-acting muscle relaxants in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry in the positive and negative ionization modes
超高效液相色谱-串联质谱法在正负电离模式下高通量同时分析人血浆中的八种中枢作用肌松剂
DOI： --
发表时间： 2011
期刊： Analytical and Bioanalytical Chemistry
影响因子： 4.3
作者： [Tadashi Ogawa, Hideki Hattori, Rina Kaneko, Kenjiro Ito, Masae Iwai, Yoko Mizutani, Tetsuya Arinobu, Akira Ishii, Hiroshi Seno]
通讯作者： Hiroshi Seno
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