Evaluation of the Wnt signal activity by the serum concentrationsof Dkk4 (Dickkopf 4) in patient with colorectal cancer.

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In this study, we focused our research on the role of Dkk4 gene which had been found asone of the genes being highly expressed in colon cancer in our previous study. In orderto investigate the clinical significance of Dkk4 expression, we examined the associationbetween the recurrence after surgery for advanced colorectal cancer and DKK4 mRNAexpression level in colorectal cancer using clinical samples. Through the analysis, wefound that the colorectal cancers with high Dkk4 mRNA expression tended to show higherrecurrence rate after surgery.Since clinical significance of Dkk4 as a biomarker to predict malignant potential andtreatment-resistance in colorectal cancer was indicated though the analysis, additionalstudies including clinical studies as well as basic studies disclosing the molecularmechanism of Dkk4 upregulation in colorectal would further clarify the significance ofDkk4 in colorectal cancer.