Analysis of differentiation process from human ES/iPS cells into vascular cell components and researches using disease-specific iPS cells with vascular disorders

我们阐明了从人ES/iPS细胞向血管细胞成分分化过程中体液因子及其受体表达的转变，我们从遗传性血管疾病患者特异性iPS细胞诱导血管内皮细胞和壁细胞，并将这些细胞与健康志愿者的细胞进行比较，在某些疾病中，我们成功地检测了一个诊断标记，并显示了血管细胞功能障碍中易感基因突变的重要性。

We clarified the transition of the expression of humoral factors and their receptors in the differentiation process from human ES/iPS cells to vascular cell components.We induced vascular endothelial cells and mural cells from patient-specific iPS cells of inherited vascular disorders, and compared these cells with those of healthy volunteers.In some diseases, we succeeded in detecting a diagnostic marker and showing the significance of a susceptibility gene mutation in vascular cell dysfunction.