Development of Novel Nano-medicine for Aortic Aneurysm regulating Monocyte/Macrophage M1/M2 Polarit

申请人展示了炎性单核细胞/巨噬细胞在腹主动脉瘤发展中的作用，并显示纳米颗粒介导的他汀类药物进入循环单核细胞抑制炎性单核细胞的募集和在载脂蛋白E缺陷的小鼠模型中腹主动脉瘤的发展。申请人展示了炎性单核细胞/巨噬细胞在腹主动脉瘤发展中的作用，并表明纳米颗粒介导的他汀类药物进入循环单核细胞抑制炎性单核细胞的募集和载脂蛋白E缺陷小鼠模型腹主动脉瘤的发展。

The applicant showed the role of inflammatory Ly6Chighmonocytes/macrophages in the development of abdominal aneurysm, and showed that nanoparticle-mediated delivery of a statin into circulation monocyte inhibited the recruitment of inflammatory monocytes and the development of abdominal aneurysm in an ApoE-deficient mouse modelThe applicant showed the role of inflammatory Ly6Chighmonocytes/macrophages in the development of abdominal aneurysm, and showed that nanoparticle-mediated delivery of a statin into circulation monocyte inhibited the recruitment of inflammatory monocytes and the development of abdominal aneurysm in an ApoE-deficient mouse model.