Development of new therapy to prevent plaque destabilization and rupture by regulating macrophage polarity

点击翻译按钮获取中文摘要

Activated (M1) macrophage plays a primary role in atherosclerotic plaque destabilization and rupture. The author hypothesized that regulating macrophage M1/M2 polarity toward anti-inflammatory M2 enable to prevent atherosclerotic plaque destabilization and rupture. In ApoE-KO mice, nanoparticle-mediated monocyte-selective treatment with PPAR-gamma agonist inhibited macrophage M1 shift, and reduced incidence of plaque rupture in the brachiocephalic arteries. These results proved the concept of a new therapy for preventing plaque rupture, by regulating macrophage polarity.