The regulation of local corticosteroid synthesis and its pathophysiological effect in the heart.

醛固酮在心力衰竭的发病机制中起关键作用。我们在此研究了局部醛固酮合成的调控及其在心脏中的病理生理作用。我们证明，高葡萄糖条件促进心肌细胞醛固酮合成酶的表达。此外，短期的醛固酮刺激被发现是通过矿物皮质激素受体不依赖的方式急性激活胰岛素信号来保护心脏的。这些结果为醛固酮以前未知的作用提供了新的见解，作为病理条件下的代偿机制，如心力衰竭，葡萄糖成为代谢和ATP生成的重要优先底物。

Aldosterone plays a pivotal role in the pathogenesis of heart failure. We herein investigated the regulation of the local aldosterone synthesis and its pathophysiological effects in the heart. We demonstrated that high glucose conditions promote the expression of aldosterone synthase in cardiomyocytes. Moreover, a short-term aldosterone stimulation is found to be cardioprotective through the acute activation of insulin signaling in a mineralocorticoid receptor-independent manner. These results provide new insight into the previously unknown role of aldosterone, as a compensatory mechanism under the pathological conditions, such as heart failure, where glucose becomes an important preferential substrate for metabolism and ATP generation.