Physiological and pathophysiological effects of aldosterone on cardiomyocytes through a dynamic regulation of insulin signaling.

醛固酮和胰岛素信号在心力衰竭的发病机制中起着关键作用。这项研究表明，在心肌细胞中，醛固酮对胰岛素信号具有双相活性。后者是通过糖皮质激素受体途径发挥保护作用，而前者则是通过短暂加速糖代谢发挥保护作用。目前的数据表明，在心力衰竭中，可能存在激活的醛固酮合成的生理作用。

Aldosterone and insulin signaling both play pivotal roles in the pathogenesis of heart failure. This study demonstrates that aldosterone exerts biphasic activity on insulin signaling in cardiomyocytes. While the latter is detrimental through mineralocorticoid receptor pathway, the former is protective pathway through the transient acceleration of glucose metabolism. The present data indicate that there may be a physiological role of aldosterone synthesis activated in heart failure.