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Effect of imatinib in bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation

Effect of imatinib in bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation
伊马替尼治疗异基因造血干细胞移植后闭塞性细支气管炎综合征的疗效
批准号:
23790901
负责人:
WASEDA Yuko
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
翻译
在小鼠肺移植模型中,当我们使用c-kit敲除模型作为供体时,BO被显著控制。我们有可能通过控制供体的c-kit来减少BO,这是肺移植后最大的并发症。因此,我们考虑用伊马替尼减少BO的可能性。
英文摘要
In the mouse lung transplantation model, BO was significantly controlled when we used the c-kit knockout model as donor. We had the possibility to be able to reduce BO, which is the biggest complications after the lung transplantation, by controlling c-kit of the donor. Therefore, We thought about the possibility that we could decrease BO with imatinib.
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会议论文
The role of c-Kit in mice model of heterotopic tracheal transplantation
  • 批准号:
    25860639
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.66万
  • 财政年份:
    2013
  • 负责人:
    WASEDA Yuko
  • 依托单位:
海外基金