Development of strategy for treatment of secondary hyperparathyroidism based on clinical and cost-effectiveness

基于临床和成本效益制定继发性甲状旁腺功能亢进症的治疗策略

• 批准号: 23790958
• 负责人: KOMADA Hirotaka
• 金额: $ 2.5万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790958/
• 关键词: 人工透析学; 観察研究; 費用対効果分析; 二次性副甲状腺機能亢進症; シナカルセト塩酸塩; 99mTc-MIBIシンチグラフィ; 炭酸ランタン

The objective of this study is to determine a reasonable strategy for treatment of secondary hyperparathyroidism based on clinical and cost-effectiveness.In the cost-effectiveness analysis of cinacalcet hydrochloride for severe secondary hyperparathyroidism, we showed that the use of cinacalcet is likely to be cost-effective for only those who cannot undergo parathyroidectomy (Komaba H et al. Am J Kidney Dis 60: 262-271, 2012).In the cost-effectiveness analysis of 99m_Tc-MIBI scintigraphy, we showed that this method is likely to be cost-effective for preoperative identification of ectopic parathyroid glands in hemodialysis patients with persistent or recurrent secondary hyperparathyroidism (Komaba H et al. 49th ERA-EDTA Congress, Paris).Finally, using retrospective cohort data of 2,292 maintenance hemodialysis patients, we demonstrated that treatment with lanthanum carbonate, a novel phosphate bidder, is independently associated with survival benefit among those with uncontrolled hyperphosphatemia (Komaba H et al.50th ERA-EDTA Congress, Istanbul).

这项研究的目的是根据临床和成本效益确定治疗继发性甲状旁腺功能亢进的合理策略。在盐酸桂钙素治疗严重继发性甲状旁腺功能亢进症的成本效益分析中，我们表明，只有那些不能接受甲状旁腺切除术的人，使用桂钙素可能是具有成本效益的(Komaba H等人)。Am J Kidney Dis 60：262-271,2012)。在99m_TC-MIBI核素扫描的成本-效果分析中，我们显示该方法对于持续或复发继发性甲状旁腺功能亢进的血液透析患者的异位甲状旁腺的术前识别可能具有成本效益(Komaba H等人)。最后，使用2,292名维持性血液透析患者的回顾队列数据，我们证明了碳酸镧的治疗与那些未受控制的高磷血症患者的生存益处独立相关(Komaba H等人.第50届ERA-EDTA大会，伊斯坦布尔)。

项目成果

Cost-Effectiveness of Cinacalcet Hydrochloride for Hemodialysis Patients With Severe Secondary Hyperparathyroidism in Japan

• DOI: 10.1053/j.ajkd.2011.12.034
• 发表时间: 2012-08-01
• 期刊: AMERICAN JOURNAL OF KIDNEY DISEASES
• 影响因子: 13.2
• 作者: Komaba, Hirotaka;Moriwaki, Kensuke;Fukagawa, Masafumi
• 通讯作者: Fukagawa, Masafumi

Cost-effectiveness of 99mTc-MIBI scintigraphy for haemodialysis patients with persistent or recurrent hyperparathyroidism in Japan

99mTc-MIBI 闪烁扫描在日本治疗持续性或复发性甲状旁腺功能亢进症的血液透析患者的成本效益

• 发表时间: 2012
• 作者: Komaba H;Moriwaki K;Kakuta T;Fukagawa M
• 通讯作者: Fukagawa M

Lanthanum carbonate and survival in maintenance haemodialysis patients

碳酸镧与维持性血液透析患者的生存率

• 发表时间: 2013
• 作者: Komaba H;Kakuta T;Suzuki H;Suga T;Fukagawa M
• 通讯作者: Fukagawa M