Investigation of the novel biological role of neuromedin S

采用高灵敏度放射免疫分析法研究了神经介质S （NMS）在大鼠脑内的区域分布。在下丘脑、中脑和延髓桥中发现了高含量的NMS肽，而NMS mRNA仅在下丘脑中大量表达。这些mRNA和肽的不同分布表明源自下丘脑NMS神经元的神经纤维投射到脑干。这些结果提示了脑干内NMS的新的、未知的生理作用。

The regional distribution of neuromedin S (NMS) in the rat brain was investigated using a highly sensitive radioimmunoassay. A high content of NMS peptide was found in the hypothalamus, midbrain, and pons-medulla oblongata, whereas abundant expression of NMS mRNA was detected only in the hypothalamus. These differing distributions of the mRNA and peptide suggest that nerve fibers originating from hypothalamic NMS neurons project into the brainstem. These results suggest novel, unknown physiological roles of NMS within the brainstem.