Inhibitory effect of IL-16 on allergic diseases

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This study aims to examine the role of IL-16 produced by CD8^+ T cells in contact dermatitis. Rag-2-deficient mice reconstituted with IL-16-deficient CD8^+ T cells exhibited severe late-phase inflammatory response and most of mice died around 7 days after hapten application. IL-17A concentration was significantly elevated in sera of IL-16-deficient CD8^+ T cells-transferred Rag2-deficient mice. In addition, increase of GOT activity and decrease of albumin/globulin ratio were observed in sera of these mice. These results indicate that IL-16 produced by CD8^+ T cells plays an inhibitory role in late-phase reaction of contact dermatitis, suggesting the existence of immunomodulatory mechanism by CD8^+ regulatory T cells.