Involvement of human lung mast cell activation through PAF receptor in severe asthma

点击翻译按钮获取中文摘要

In this study, we demonstrated for the first time that PAF induces histamine release from human lung mast cells but not human skin mast cells. PAF receptor on human peripheral blood-derived cultured mast cells coupled to pertussis toxin-sensitive Gi protein and activated PLC・2 and PLC・1 in response to PAF. These observations have important implications for our understanding of the mechanisms of acute allergic diseases, in particular asthma.