Basic study of autologous transplantation of ex vivo expanding macrophages to secondary lymphedema

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We tried to establish postoperative lymphedema mouse model but it was failed within the period. The possible reasons are (1)difficulty of visualizing lymphatics by blue dye. (2)edema was not significantly observeded because of quaruped walking. (3)difficulty of the detection of lymph nodes. We next used diabetic wound mo del which is one of the established model of impaired lymphatic function. We focused on statin which can be possible stimulator of macrophages. Statin application significantly improve lymphangiogenesis in diabetic wound model via promoting macrophage func tion.