The effects of statin on lymphangiogenesis in impaired wound healing

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The present study showed topical application of simvastatin promoted lymphangiogenesis as well as angiogenesis during wound healing in genetically diabetic mice. These results suggested that both pre-existing lymphatic endothelial cells and infiltrating macrophages might contribute to newly organized vessels induced by simvastatin. In conclusion, a simple strategy of topically applied simvastatin may have significant therapeutic potential for enhanced wound healing in patients with impaired microcirculation such as occurs in diabetes.