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Regulation of intracellular Ca2+ concentration in epidermal keratinocytes: Study for coordination in three calcium pumps and their roles for epidermal differentiation

Regulation of intracellular Ca2+ concentration in epidermal keratinocytes: Study for coordination in three calcium pumps and their roles for epidermal differentiation
表皮角质形成细胞内Ca2+浓度的调节：三个钙泵的协调及其对表皮分化作用的研究
批准号：
23791298
负责人：
HAMADA Takahiro
金额：
$2.66万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791298/
关键词：
遺伝学遺伝子ゲノム単一遺伝子病遺伝性皮膚疾患カルシウムポンプ皮膚病理学

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中文摘要
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英文摘要
Hailey-Hailey disease (HHD) and Darier disease (DD) are caused by mutations in the genes encoding the intracellular calcium pumps. In this study, we investigated the roles for intracellular Ca2+ homeostasis and epidermal differentiation in these calcium pumps, using cultured epidermal keratinocytes (KCs) derived from patients with HHD and DD. HHD KCs revealed the altered response of Ca2+ release from intracellular stores to ATP stimulation, but not by constitutive elevation of cytoplasmic Ca2+. The expressions of several calcium-binding proteins and epidermal differentiation-mediated proteins (e.g.calmodulin-like 5 and loricrin) were increased in HHD KCs compared to normal control.
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Impaired innate immunity to HSV in Hailey-Hailey disease is caused by TLR9 defect through abnormal cytoplasmic Ca2+ signalling.
Hailey-Hailey 病中针对 HSV 的先天免疫受损是由 TLR9 缺陷通过异常的细胞质 Ca2 信号传导引起的。
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Hamada T, Ogawa M, Ishii N, Ono F, Matsuda M, Sakaguchi S, Karashima T, Nakama T, Dainichi T, Tsuruta D, Yasumoto S, Hashimoto T., Hamada T]
通讯作者： Hamada T
Novel adenosine triphosphate (ATP)-binding cassette, subfamily A, member 12 (ABCA12) mutations associated with congenital ichthyosiform erythroderma. Br
与先天性鱼鳞病样红皮病相关的新型三磷酸腺苷 (ATP) 结合盒、A 亚家族、成员 12 (ABCA12) 突变。
DOI： 10.1111/j.1365-2133.2011.10516.x
发表时间： 2012
期刊： J Dermatol
影响因子： 3.1
作者： [Fukuda S, Hamada T, Ishii N, Sakaguchi S, Sakai K, Akiyama M, Shimizu H, Masuda K, Izu K, Teye K, Tsuruta D, Karashima T, Nakama T, Yasumoto S, Hashimoto T.]
通讯作者： Hashimoto T.
Studies of cultured Hailey-Hailey disease keratinocytes revealed pathogenic role of the mutations and novel mechanism in Ca2+ homeostasis
对培养的 Hailey-Hailey 病角质形成细胞的研究揭示了突变的致病作用和 Ca2 稳态的新机制
DOI： --
发表时间： 2012
期刊：
影响因子： --
作者： [Matsuda M, Hamada T, Ishii N, Sakaguchi S, Murai Y, Ohata C, Furumura M, Tanaka E, Hashimoto T.]
通讯作者： Hashimoto T.
Impaired innate immunity to HSV in Hailey-Hailey disease is caused by TLR9 defect through abnormal cytoplasmic Ca2+ signalling
Hailey-Hailey 病中 HSV 的先天免疫受损是由 TLR9 缺陷通过异常的细胞质 Ca2 信号传导引起的
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Hamada T, Ogawa M, Ishii N, Ono F, Matsuda M, Sakaguchi S, Karashima T, Nakama T, Dainichi T, Tsuruta D, Yasumoto S, Hashimoto T.]
通讯作者： Hashimoto T.
共 11 条
    Identification of plant RNA granules with electron microscopy
    • 批准号：
      26650090
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.5万
    • 财政年份：
      2014
    • 负责人：
      HAMADA Takahiro
    • 依托单位：
      The University of Tokyo
    Mutation analyses of inherited keratodermas and gene identification for inherited keratodermas of unknown pathology
    • 批准号：
      19790806
    • 项目类别：
      Grant-in-Aid for Young Scientists (B)
    • 资助金额：
      $2.42万
    • 财政年份：
      2007
    • 负责人：
      HAMADA Takahiro
    • 依托单位：
      Kurume University
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