Clinical study of novel treatment for drug-inducedhyperprolactinemia

本初步研究旨在评价低剂量普拉克索（一种优先多巴胺D3受体激动剂）治疗抗精神病药诱导的高泌乳素血症的疗效和耐受性。选择40例高泌乳素血症的男性精神分裂症患者。少数受试者正在接受连续低剂量普拉克索治疗。我们报告了一例利培酮引起的高催乳素血症和艾德，两例均成功改善，无任何不良反应，如精神病恶化。

This pilot study aimed to evaluate the efficacy and tolerability of a low dose of pramipexole, a preferential dopamine D3 receptor agonist, in the treatment of antipsychotics -induced hyperprolactinemia. Forty male patients with schizophrenia who were showing hyperprolactinemia were selected. A few subjects are under treatment withadjunctive low-dosage pramipexole. We reported one of the cases who showed risperidone-induced hyperprolactinemia and ED, each of which was improved successfully without any adverse effect such as worsening psychosis.