Establishment of coil-assisted NBCA embolization technique-Toward the standardization of vascular embolization

弹簧圈辅助NBCA栓塞技术的建立——迈向血管栓塞标准化

• 批准号: 23791381
• 负责人: ABO Daisuke
• 金额: $ 2.66万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791381/
• 关键词: 血管塞栓術; コイル; N-Butylcyanoacrylate; 標準化

To establish the methodology and assess feasibility of coil-assisted N-butyl-2-cyanoacrylate (NBCA) embolization technique, thirty-eight arteries of three swine were embolized as target arteries.In half of the target arteries, a single anchoring coil was placed (Group A; n=19). In the remaining, a coil mixture made by coil-in-coil technique was used(Group B; n=19). In both groups, 50% NBCA-lipiodol mixture (50%NBCA) was injected via microcatheter Flow delay after coil placement, the length of cast formation over the coil mass(＞1cm) and cast fragmentation were evaluated.As a result, all arteries occluded just after embolization. Flow delay after coil placement occurred more frequently in Group B (11/19) than in Group A (4/19) (p=0.0448). Cast formation over the coil mass and cast fragmentation were observed less frequently in Group B (3/19 and 4/19, respectively) than in Group A (9/19 and 7/19, respectively) (p=0.0463 and 0.0489). Cast formation over the coil mass occurred less frequently in the arteries with flow delay (1/15), compared to their counterparts (13/23) (p=0.0021).Cast fragmentation did not occur in any artery with flow delay (p＜0.001).From these results, we concluded that coil-assisted NBCA embolization technique is feasible for embolization in short segment of target vessels, if the coil induces a sufficient flow delay. Coil-in-coil technique is recommended to enhance flow delay.

为建立弹簧圈辅助NBCA栓塞技术的方法学和评价其可行性，选择3只猪的38支动脉作为靶动脉，其中1/2的靶动脉放置单个锚定弹簧圈（A组，n=19）。在其余的实验中，使用通过线圈中线圈技术制备的线圈混合物（B组; n=19）。两组均经微导管注入50%NBCA-碘油混合液（50%NBCA），观察栓塞后血流延迟、栓塞段上铸型长度（>1cm）及铸型破碎情况。与A组（4/19）相比，B组（11/19）中弹簧圈放置后的血流延迟发生率更高（p=0.0448）。与A组（分别为9/19和7/19）相比，B组（分别为3/19和4/19）中观察到弹簧圈块上的管型形成和管型碎裂的频率较低（p=0.0463和0.0489）。与血流延迟动脉（13/23）相比，血流延迟动脉（1/15）的弹簧圈团块上的管型形成较少发生（p=0.0021）在任何血流延迟的动脉中均未发生管型碎裂（p<0.001）。从这些结果中，我们得出结论，弹簧圈辅助NBCA栓塞技术对于短段靶血管的栓塞是可行的，如果线圈引起足够的流动延迟。建议采用弹簧圈中弹簧圈技术来增强流动延迟。

项目成果

膵頭十二指腸切除術後膵液瘻に対する非観血的内瘻化

无创内瘘治疗胰十二指肠切除术后胰液瘘

• 发表时间: 2011
• 作者: Abo D;Hasegawa Y;Sakuhara Y;Terae S;Shimizu T;Tanaka E;Hirano S;Shirato H;阿保大介，作原祐介，長谷川悠，曽山武士，森田亮，坂本圭太，白土博樹，寺江聡，清水匡，田中栄一，平野聡;阿保大介，長谷川悠，作原祐介，森田亮，曽山武士，白土博樹，寺江聡，清水匡，田中栄一，平野聡51.阿保大介，長谷川悠，作原祐介，森田亮，曽山武士，白土博樹，寺江聡，清水匡，田中栄一，平野聡
• 通讯作者: 阿保大介，長谷川悠，作原祐介，森田亮，曽山武士，白土博樹，寺江聡，清水匡，田中栄一，平野聡51.阿保大介，長谷川悠，作原祐介，森田亮，曽山武士，白土博樹，寺江聡，清水匡，田中栄一，平野聡

豚動脈を用いたコイル併用 n-butyl-2-cianoacrylate (NBCA) 塞栓術の実現性の検討

猪动脉2-氰基丙烯酸正丁酯（NBCA）栓塞联合弹簧圈的可行性研究

• 发表时间: 2013
• 作者: Abo D;Hasegawa Y;Sakuhara Y;Terae S;Shimizu T;Tha KK;Tanaka E;Hirano S;Kondo S;Shirato H;安井博宣,山盛徹,和田悠佑,山住雅之,稲波修;阿保大介
• 通讯作者: 阿保大介

Feasibility of a dual microcatheter-dual interlocking detachable coil technique in preoperative embolization in preparation for distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer

• DOI: 10.1007/s00534-011-0455-9
• 发表时间: 2012-07-01
• 期刊: JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
• 影响因子: 3
• 作者: Abo, Daisuke;Hasegawa, Yu;Shirato, Hiroki
• 通讯作者: Shirato, Hiroki

腹腔動脈幹合併切除兼尾側膵切除（DP-CAR）術前総肝動脈塞栓術の検討～dual microcatheter法とconventional法との比較～

腹腔干切除联合尾部胰腺切除术（DP-CAR）术前肝总动脉栓塞的探讨 - 双微导管方法与常规方法的比较 -

• 发表时间: 2011
• 作者: Abo D;Hasegawa Y;Sakuhara Y;Terae S;Shimizu T;Tanaka E;Hirano S;Shirato H;阿保大介，作原祐介，長谷川悠，曽山武士，森田亮，坂本圭太，白土博樹，寺江聡，清水匡，田中栄一，平野聡
• 通讯作者: 阿保大介，作原祐介，長谷川悠，曽山武士，森田亮，坂本圭太，白土博樹，寺江聡，清水匡，田中栄一，平野聡

豚動脈を用いたコイル併用N-butyl-2-cyanoacrylate (NBCA)塞栓術の実現性の検討

猪动脉线圈组合 N-2-氰基丙烯酸正丁酯 (NBCA) 栓塞的可行性研究

• 作者: Abo D;Hasegawa Y;Sakuhara Y;Terae S;Shimizu T;Tanaka E;Hirano S;Shirato H;阿保大介，作原祐介，長谷川悠，曽山武士，森田亮，坂本圭太，白土博樹，寺江聡，清水匡，田中栄一，平野聡;阿保大介，長谷川悠，作原祐介，森田亮，曽山武士，白土博樹，寺江聡，清水匡，田中栄一，平野聡51.阿保大介，長谷川悠，作原祐介，森田亮，曽山武士，白土博樹，寺江聡，清水匡，田中栄一，平野聡;阿保大介
• 通讯作者: 阿保大介