Study for radiotherapy-induced tumor specific immunity.

放射治疗诱导的肿瘤特异性免疫研究。

• 批准号: 23791393
• 负责人: YOSHIMOTO Yuya
• 金额: $ 2.66万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791393/
• 关键词: 抗腫瘍免疫; 放射線治療; 癌精巣抗原

The aim of this study is to examine weather a radiation therapy can induce specific anti-tumor immunity in human cancer patients. ELISPOT assay revealed that tumor specific CTLs were induced in the patients after radiation therapy. The CTLs recognized cancer testis antigen derived peptides that were expressed on esophageal cancer cells. Furthermore, a role of the CTLs was also investigated. In mouse tumor models, a radiation therapy also induced tumor specific CTLs. The radiation therapy failed when CTLs were removed by using specific antibody, suggesting that anti-tumor immunity, such as the CTLs, was required for success of the therapy.

本研究的目的是检查放射治疗是否可以在人类癌症患者中诱导特异性抗肿瘤免疫。ELISPOT检测显示放疗后患者体内产生了肿瘤特异性CTL。CTL识别食管癌细胞上表达的癌睾丸抗原衍生肽。此外，还研究了CTL的作用。在小鼠肿瘤模型中，放射疗法也诱导肿瘤特异性CTL。当使用特异性抗体去除CTL时，放射治疗失败，这表明抗肿瘤免疫，如CTL，是治疗成功所必需的。

项目成果

放射線による抗腫瘍免疫の活性化

通过辐射激活抗肿瘤免疫力

• 发表时间: 2012
• 作者: 吉本由哉;鈴木義行;三村耕筰;河野浩二;中野隆史
• 通讯作者: 中野隆史

放射線による抗腫瘍免疫誘導に関する検討

辐射诱导抗肿瘤免疫的研究

• 发表时间: 2012
• 作者: 吉本由哉 ;鈴木義行;三村耕作;河野浩二;中野隆史
• 通讯作者: 中野隆史

放射線と免疫細胞療法の併用療法

放射治疗和免疫细胞治疗的联合治疗

• 发表时间: 2012
• 作者: Hiroyuki KATOH;Hitoshi ISHIKAWA;Takuya KAMINUMA;Tomoaki TAMAKI;Katsuyuki SHIRAI;Hiroshi MATSUI;Tatsuya OHNO;Kazuto ITO;Kazuhiro SUZUKI;Takashi NAKANO;吉本由哉
• 通讯作者: 吉本由哉

Immunogenic Tumor Cell Death Induced by Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma

• DOI: 10.1158/0008-5472.can-12-0851
• 发表时间: 2012-08-15
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Suzuki, Yoshiyuki;Mimura, Kousaku;Kono, Koji
• 通讯作者: Kono, Koji

Requirement of Anti- tumor Immunity and Enhancement byCTL-associated Antigen-4 Blockade on Therapeutic Efficacy of Radiation Therapy in a Mouse Tumor Model

小鼠肿瘤模型中抗肿瘤免疫的要求和 CTL 相关抗原 4 阻断对放射治疗疗效的增强

• 发表时间: 2012
• 作者: Yoshimoto Y;Suzuki Y;Mimura K;Kono K and Nakano T
• 通讯作者: Kono K and Nakano T