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低強度運動介入が高齢者の高次認知機能に及ぼす影響－ｆＮＩＲＳによる神経基盤の検討

低强度运动干预对老年人高级认知功能的影响——使用 fNIRS 检查神经基础

基本信息

批准号：
12J01926
负责人：
兵頭和樹
金额：
$ 1.73万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2012
资助国家：
日本
起止时间：
2012-04-01 至 2015-03-31
项目状态：
已结题

项目摘要

本研究は、低体力者でも適応可能な低強度の運動トレーニングが高齢者の前頭前野機能に与える効果の脳内メカニズムを、最新の脳機能イメージング装置である近赤外線分光法装置(fNIRS)を用いて明らかにすることを目的としている。昨年度までで、一過性の低・中強度運動が健常高齢者の実行機能（前頭前野が司る高次認知機能）を高める脳内機構を明らかにしてきた（Hyodoら, Neurobiol Aging,2012 ; Byunら、Neuroimage,2014）。また、低強度運動で向上する有酸素能力である換気性作業閾値（VTが高い高齢者は実行機能が高く、その脳内機構として、若者型の左半球優位の脳活動が保たれていたことから（論文投稿中）、本年度は、VTを高める3ヶ月間の低強度運動介入が健常高齢者の実行機能に与える影響とその脳内機構について検討した。健常高齢者を通常生活を送らせる安静群と、3ヶ月間低強度運動トレーニング(週3回、1時間、35~40%VO2peakの自転車運動)を行なう低強度運動群に振り分けた。両群とも、介入前後で漸増運動負荷試験によるVT測定、ストループ課題による実行機能測定をおこなった。課題中の前頭前野の活動はfNIRSで測定した。有酸素能力に関して、低強度運動群ではVTの低下が抑えられて運動効果が見られた。また、認知課題成績は、低強度運動群でのみストループ課題の中でも実行機能を反映するストループ干渉の反応時間において有意な短縮が見られた。本研究の結果は、わずか３ヶ月間の軽運動でも高齢者の実行機能を高める効果があることを示唆している。現在はfNIRSデータを解析中であり、その脳内機構を解明していく予定である。

In this study, people with low physical strength may be able to communicate with those with low intensity and high strength. in this study, people with low physical strength and people with low physical strength may be able to compete with those with low intensity and high strength. in this study, people with low physical strength and people with low physical strength may be able to achieve the same results as those with low physical strength and those with high physical strength. in this study, people with low physical strength and people with low physical strength may be able to achieve the same results as those with high physical strength. The latest machine can be used to verify the performance of the near-infrared spectrometer (fNIRS). In the past year, those who had sex with low, medium, strong, healthy and high levels of exercise had the ability to exercise (the former wild company had high-level knowledge of the mechanism) and the internal machinery of the high-level organization had a clear understanding of Hyodo training (Neurobiol Aging,2012; Byun training, Neuroimage,2014). High-intensity and low-intensity exercise devices have the ability to improve the performance of sex jobs (those with high levels of VT), those with high levels of exercise, those with high levels of activity in the left hemisphere, and those with high levels of activity in the left hemisphere (in the article), this year's program, During the last three months of VT training, people with high levels of health and high levels of health and high levels of exercise will be able to use their mobile phones to help people with high levels of health and health. Healthy people usually send low-intensity exercise to quiet group, low-intensity exercise in 3 months (3-round, 1-time, 35~40%VO2peak-free exercise), low-intensity exercise, low-intensity exercise, and low-intensity exercise. Before and after the intervention, the mobile phone can measure the load of the VT, and the mobile phone will be able to measure the target. In the project, the previous field activity called fNIRS measurement. It has the ability of acid, low intensity, low intensity, low VT, low strength, low strength, low intensity, low intensity, low It is known that when the problem is caused, the low-strength mobile group can reflect the response time and the intention is to make a short response. According to the results of this study, those with high levels of activity during the last three months can have a high performance in terms of financial performance. At present, in the analysis of the fNIRS information system, the internal organs of the government are responsible for explaining the predetermined conditions of the system.