Studies on the outbreak mechanism of hereditary dilated cardiomyopathy in dogs

对一个美国可卡犬（ACS）家系的扩张型心肌病合并白内障的临床情况进行了分析。分析了参与扩张型心肌病发病的蛋白质表达和各种基因分析。因此，本研究发现ACS家系中存在扩张型心肌病的爆发。心肌病和白内障的发生与骨骼肌中α B-晶体蛋白（α B-crystallin，α B-AB）表达水平的降低有关。结果表明，在心肌病患者中，存在着CRAAA或CRAAB基因氨基酸非编码区的单核苷酸多态性，提示基因多态性与心肌病的发生有关。

Clinical conditions of the dilated cardiomyopathy in the American Cocker spaniel (ACS) family developed dilated cardiomyopathy and a cataract were analyzed. Protein expressions and various gene analyses participating in outbreak of the dilated cardiomyopathy were analyzed. As a result, the outbreak of dilated cardiomyopathy in ACS family was found in this study. Outbreaks of cardiomyopathy and cataract were associated with the decrease of the expression level of Alpha B-crystallin (CRYAB) in the skeletal muscle. Single nucleotide polymorphisms of the amino acid non-coding regions of CRYAA or CRYAB gene were found, suggesting a relationship between cardiomyopathy and genetic polymorphism.