Analysis of non-coding RNA expression in stem and progenitor cells in mouse testes

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In mice, we found that the significant progression of heterochromatin formation occurred at the transition from stem to progenitor cells in adult male germ cells. In addition, the gene expression pattern was also significantly changed at the transition. Since it has been reported that non-coding RNA plays an important role in heterochromatin formation, resulting in changing of gene expression profiles, we analyzed and compared the expression profiles of miRNA and long non-coding RNA between stem cells and progenitor cells in adult male germ cells. We found several miRNA and long non-coding RNA that were specifically expressed in each of the cell populations.