Search for useful biomarkers for evaluation of antipruritic agents
Search for useful biomarkers for evaluation of antipruritic agents
批准号:
23659316
负责人:
KURAISHI Yasushi
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
点击翻译按钮获取中文摘要
英文摘要
We searched useful biomarkers for evaluation of antipruritic agents in serum and plasma, using mouse models for chronic pruritus. Adrenocorticotropic hormone (ACTH) was found to be reduced in the plasma of mice with chronic pruritus, and this decrease was reversed by agents that inhibited itching behaviors. Thus, ACTH may be useful biomarkers for itching and itch-associated stress. Granzyme A and some serum protein, changes of which were revealed by proteomic analysis, are still analyzed as possible pruritus biomarkers.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
アレルギー性疾患のバイオマーカーおよびその利用
过敏性疾病的生物标志物及其用途
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[]
通讯作者:
Roles of proteases and proteinase-activated receptor 2 in itching of pruritic diseases
-
批准号:23390153
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.9万
-
财政年份:2011
-
负责人:KURAISHI Yasushi
-
依托单位:
The role of the membrane phospholipid metabolite lipoxin A4 in allergic itch
-
批准号:19390020
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.48万
-
财政年份:2007
-
负责人:KURAISHI Yasushi
-
依托单位:
MECHANISMS OF ALLERGIC ITCH
-
批准号:10470509
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$7.74万
-
财政年份:1998
-
负责人:KURAISHI Yasushi
-
依托单位:
Studies on endogenous itch mediators and their interaction
-
批准号:08457635
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.52万
-
财政年份:1996
-
负责人:KURAISHI Yasushi
-
依托单位:
Establishment of the estimation method for analgesia using stress-induced hyperalgesic animals
-
批准号:07557379
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$0.38万
-
财政年份:1995
-
负责人:KURAISHI Yasushi
-
依托单位:
Change of glutamate and tachykinin receptors in chronic pain model animals (molecular biological and pharmacological study)
-
批准号:04454542
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.42万
-
财政年份:1992
-
负责人:KURAISHI Yasushi
-
依托单位:
Mechanism of pharmacological action of nootropics in the hippocampus
-
批准号:02454496
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$3.9万
-
财政年份:1990
-
负责人:KURAISHI Yasushi
-
依托单位: