Analyses on the effectiveness of cancer screening by mathematical models to improve participation rates

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The best strategy for breast cancer screening in Japan was analyzed by mathematical models. In the case where the beginning age of the screening is changed to early age from 50 to 40 years old, mortality reduction rate per one screening was predicted to decrease whereas the false positives were predicted to increase. In the determination of the best strategy, the evaluation of harmful effects of screening was clarified to play an important role. In addition to theoretical analyses, background and psychological factors related to female participants of screening were analyzed by a questionnaire survey. The introduction of intervention program and the realization of promoting environment were concluded to be important to improve the female participation rates.