Generation of a novel research area "sex difference in cardiovascular system based on XY chromosomes"

全新研究领域“基于XY染色体的心血管系统性别差异”的产生

• 批准号: 23659413
• 负责人: FURUKAWA Tetsushi
• 金额: $ 2.33万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659413/
• 关键词: 分子心臓病態学; 心臓; 性差; 循環器; 性染色体

There is gender difference in susceptibility to certain diseases and responses to drugs. This is partly attributed to the different gonad determined by SRY gene on the Y-chromosome, and resultant different sex hormones between male and female. However, the difference in the XY chromosome also contributes to the gender difference. The Y-chromosome containing about 80 genes is present only in male. In contrast, in female (YY) 10% of genes (about 100 genes) on the X-chromosome do not execute inactivation and thereby female has copy number for these 100 genes twice as many as male. However, the gender difference caused by the XY chromosome is poorly understood mainly because of technical deficit. In this project, we established XX♀、XX♂、XY♀、XY♂ mice by cross-hybridizing XY- SRY mice with wildtype XX female mice, and we collected the baseline data for cardiovascular functions.

在某些疾病的易感性和对药物的反应方面存在性别差异。这可能与Y染色体上SRY基因决定的性腺不同，导致雌雄性激素水平不同有关。然而，XY染色体的差异也导致了性别差异。Y染色体包含约80个基因，仅存在于男性中。相反，在女性（YY）中，X染色体上10%的基因（约100个基因）不执行失活，因此女性的这100个基因的拷贝数是男性的两倍。然而，由于技术上的缺陷，对XY染色体引起的性别差异知之甚少。在本项目中，我们通过XY-SRY小鼠与野生型XX雌性小鼠交叉杂交建立了XX_（10）、XX_（10）、XY_（10）、XY_（10）小鼠，并收集了心血管功能的基线数据。

项目成果

Scna1a mutant knock-in mouse revealed sudden unexpected death in epilepsy (SUDEP) in Dravet syndrome as cardiac arrhythmia origin

Scna1a 突变敲入小鼠揭示 Dravet 综合征中癫痫意外死亡 (SUDEP) 是心律失常的起源

• 发表时间: 2012
• 作者: origome Y;Koizumi A;Takahashi Y;Ogiwara I;Furukawa T
• 通讯作者: Furukawa T

NOS1AP destruction enhanced susceptibility to oxidative stress in doxorubicin-induced cardiomyopathy

NOS1AP 破坏增强阿霉素诱导的心肌病对氧化应激的易感性

• 发表时间: 2011
• 作者: Tsuchiya J;Sasano T;Okamura T;Kato N;Furukawa T
• 通讯作者: Furukawa T

そうだったのか！臨床に役立つ不整脈の基礎

是这样吗！

• 发表时间: 2012
• 作者: Shimizu T;Tanaka S;Satoh K;Fukumoto Y;Shimokawa H;中谷晴昭
• 通讯作者: 中谷晴昭

Involvement of PDE2 in a localized regulation of the L-type Ca^<2+> channels by progesterone

PDE2 参与黄体酮对 L 型 Ca^2 > 通道的局部调节

• 发表时间: 2013
• 作者: Kurokawa J;Kodama M;Goryoda S;T Furukawa
• 通讯作者: T Furukawa

Sex and Gender Differences in signal transductions at cardiomyocytes

心肌细胞信号转导的性别差异

• 发表时间: 2013
• 作者: Goryoda S;Kurokawa J et al;黒川洵子;黒川洵子;Kurokawa J;Kurokawa J;Kurokawa J
• 通讯作者: Kurokawa J