Generation of a novel research area "sex difference in cardiovascular system based on XY chromosomes"

全新研究领域“基于XY染色体的心血管系统性别差异”的产生

• 批准号: 23659413
• 负责人: FURUKAWA Tetsushi
• 金额: $ 2.33万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659413/
• 关键词: 分子心臓病態学; 心臓; 性差; 循環器; 性染色体

There is gender difference in susceptibility to certain diseases and responses to drugs. This is partly attributed to the different gonad determined by SRY gene on the Y-chromosome, and resultant different sex hormones between male and female. However, the difference in the XY chromosome also contributes to the gender difference. The Y-chromosome containing about 80 genes is present only in male. In contrast, in female (YY) 10% of genes (about 100 genes) on the X-chromosome do not execute inactivation and thereby female has copy number for these 100 genes twice as many as male. However, the gender difference caused by the XY chromosome is poorly understood mainly because of technical deficit. In this project, we established XX♀、XX♂、XY♀、XY♂ mice by cross-hybridizing XY- SRY mice with wildtype XX female mice, and we collected the baseline data for cardiovascular functions.

对某些疾病的敏感性和对药物的反应存在性别差异。这部分归因于由Sry基因在Y染色体上确定的不同性腺，以及在雄性和女性之间导致不同的性马。但是，XY染色体的差异也会导致性别差异。仅在男性中存在含有约80个基因的Y染色体。相反，在X染色体上的雌性（YY）中，10％的基因（约100个基因）不会执行失活，因此，女性的这100个基因的拷贝数是雄性的两倍。但是，XY染色体引起的性别差异主要是由于技术辩护而理解的。在这个项目中，我们通过使用WildType XX雌性小鼠跨杂交Xy-sry小鼠建立了XX♀，XX♀，XY♀，XY♀♀小鼠，并收集了心血管功能的基线数据。

项目成果

Stretch of Atrial Myocytes Stimulates Recruitment of Macrophages via ATP Released Through Gap-Junction Channels

• DOI: 10.1254/jphs.12202fp
• 发表时间: 2012-12-01
• 期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
• 影响因子: 3.5
• 作者: Oishi, Sakiko;Sasano, Tetsuo;Furukawa, Tetsushi
• 通讯作者: Furukawa, Tetsushi

Sex and Gender Differences in signal transductions at cardiomyocytes

心肌细胞信号转导的性别差异

• 发表时间: 2013
• 作者: Goryoda S;Kurokawa J et al;黒川洵子;黒川洵子;Kurokawa J;Kurokawa J;Kurokawa J
• 通讯作者: Kurokawa J

Characterization of human induced pluripotent stem cell-derived cardiomyocytes

人诱导多能干细胞来源的心肌细胞的表征

• 发表时间: 2011
• 作者: 李敏;黒川洵子ら
• 通讯作者: 黒川洵子ら

Scna1a mutant knock-in mouse revealed sudden unexpected death in epilepsy (SUDEP) in Dravet syndrome as cardiac arrhythmia origin

Scna1a 突变敲入小鼠揭示 Dravet 综合征中癫痫意外死亡 (SUDEP) 是心律失常的起源

• 发表时间: 2012
• 作者: origome Y;Koizumi A;Takahashi Y;Ogiwara I;Furukawa T
• 通讯作者: Furukawa T

そうだったのか！臨床に役立つ不整脈の基礎

是这样吗！

• 发表时间: 2012
• 作者: Shimizu T;Tanaka S;Satoh K;Fukumoto Y;Shimokawa H;中谷晴昭
• 通讯作者: 中谷晴昭