Novel role of basophil in chronic hypersensitivity pneumonitis

采用鸽粪提取物（PDE）致A/J小鼠和BALB/c小鼠慢性过敏性肺炎模型。在接下来的4周中，每周于PDE攻击前1天注射嗜碱性粒细胞特异性单克隆抗体（抗CD 200 R3，Ba 103）以去除嗜碱性粒细胞，制备病理学检查、胶原含量和几种细胞因子mRNA表达的标本。

Pigeon dropping extract(PDE) induced chronic hypersensitivity pneumonitis model using A/J mice and BALB/c mice was prepared. Basophil specific monoclonal antibody(anti-CD200R3、Ba103) was injected to the mice one day before challenge of PDE every week during the following four weeks to deplete basophils, Specimens for pathological findings, collagen contents, and mRNA expression of several cytokines were prepared.