The circadian clocks condition neuronal/endocrine/immune axis

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This study showed that the time of day-dependent variation in the skin allergic reaction observed in the sham-operated mice was absent in the mice with the physical ablation of the SCN. In addition, the time of day-dependent variation in the skin allergic reaction was absent in the mice with specific deletion of the Clock gene in mast cells. These results suggest the circadian clocks drive the daily rhythms in the skin allergic reaction by mediating temporal regulation of the nervous/endocrine/immune systems.