Crosstalk between the circadian clock circuitry and the immune system.
Crosstalk between the circadian clock circuitry and the immune system.
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DOI：
10.3109/07420528.2013.782315
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发表时间：
2013-08
影响因子：
2.8
通讯作者：
Mazzoccoli G
中科院分区：
文献类型：
--
作者：
Cermakian N;Lange T;Golombek D;Sarkar D;Nakao A;Shibata S;Mazzoccoli G
免疫系统的各种特征、组分和功能呈现每日变化。免疫活性细胞计数和细胞因子水平根据一天中的时间和睡眠-觉醒周期呈现变化。此外，不同的免疫细胞类型，如巨噬细胞、自然杀伤细胞和淋巴细胞，都含有昼夜分子时钟。免疫细胞和淋巴器官固有的生物钟，连同来自视交叉上核的中枢起搏器经由体液和神经通路的输入，调节免疫系统细胞的功能，包括它们对信号的响应及其效应器功能。其后果包括，例如，对免疫攻击的应答的每日变化（例如，细菌内毒素注射）和过敏反应的昼夜节律控制。昼夜节律-免疫连接是双向的，因为除了免疫功能的这种昼夜节律控制之外，免疫挑战和免疫介质（例如，细胞因子）在分子、细胞和行为水平上对昼夜节律具有强烈的影响。昼夜节律和免疫系统之间的这种紧密串扰对疾病具有广泛的影响，如在昼夜节律中断时癌症的较高发病率和自身免疫症状的恶化所示。
Various features, components, and functions of the immune system present daily variations. Immunocompetent cell counts and cytokine levels present variations according to the time of day and the sleep-wake cycle. Moreover, different immune cell types, such as macrophages, natural killer cells, and lymphocytes, contain a circadian molecular clockwork. The biological clocks intrinsic to immune cells and lymphoid organs, together with inputs from the central pacemaker of the suprachiasmatic nuclei via humoral and neural pathways, regulate the function of cells of the immune system, including their response to signals and their effector functions. Consequences of this include, for example, the daily variation in the response to an immune challenge (e.g., bacterial endotoxin injection) and the circadian control of allergic reactions. The circadian-immune connection is bidirectional, because in addition to this circadian control of immune functions, immune challenges and immune mediators (e.g., cytokines) were shown to have strong effects on circadian rhythms at the molecular, cellular, and behavioral levels. This tight crosstalk between the circadian and immune systems has wide-ranging implications for disease, as shown by the higher incidence of cancer and the exacerbation of autoimmune symptoms upon circadian disruption.
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影响因子：
2.8
作者：
Alfonso, TF;Celentano, AM;Golombek, DA
通讯作者：
Golombek, DA
影响因子：
15.1
作者：
Benedict, Christian;Dimitrov, Stoyan;Born, Jan
通讯作者：
Born, Jan
影响因子：
2.8
作者：
Arendt, J
通讯作者：
Arendt, J
影响因子：
2.8
作者：
Atanackovic, D;Brunner-Weinzierl, MC;Deter, HC
通讯作者：
Deter, HC
影响因子：
2.3
作者：
Arjona, Alvaro;Sarkar, Dipak K.
通讯作者：
Sarkar, Dipak K.