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Molecular mechanism of urticarial development

Molecular mechanism of urticarial development
荨麻疹发生的分子机制
批准号:
23659550
负责人:
HIRAKAWA Satoshi
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
The biochemical cleavage of VE-cadherin was found in cultured endothelial cells. Western blot analysis from cell lysates and conditioned media revealed that VE-cadherin undergoes ectodomain shedding in response to histamine, leading to the disruption of EC junctions and the induction of vascular hyperpermeability. These findings represent the development of urticaria, a pathological alteration of vasculature in the skin.
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会议论文
DOI: 10.1016/j.jdermsci.2010.09.008
发表时间: 2010-12-01
期刊: JOURNAL OF DERMATOLOGICAL SCIENCE
影响因子: 4.6
作者: [Dai, Xiuju, Sayama, Koji, Hashimoto, Koji]
通讯作者: Hashimoto, Koji
Multiple milia and comedones as a skin manifestation of systemic amyloidosis.
多发性粟丘疹和粉刺是系统性淀粉样变性的皮肤表现。
DOI: --
发表时间: 2011
期刊: European Journal of Dermatology
影响因子: 2.5
作者: [Funai N, Machida S, Ito T, Hirakawa S, Tokura Y.]
通讯作者: Tokura Y.
特許
专利
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: []
通讯作者:
DOI: 10.1371/journal.pone.0011275
发表时间: 2010-06-23
期刊: PloS one
影响因子: 3.7
作者: [Sayama K, Kajiya K, Sugawara K, Sato S, Hirakawa S, Shirakata Y, Hanakawa Y, Dai X, Ishimatsu-Tsuji Y, Metzger D, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K]
通讯作者: Hashimoto K
34
    Biological effect of VEGF-C on cultured lymphatic endothelial cells
    • 批准号:
      25670501
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2013
    • 负责人:
      HIRAKAWA Satoshi
    • 依托单位:
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    • 批准号:
      23390283
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.48万
    • 财政年份:
      2011
    • 负责人:
      HIRAKAWA Satoshi
    • 依托单位:
    Induction of lymphangiogenesis by membrane-binding growth factors
    • 批准号:
      20591348
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2008
    • 负责人:
      HIRAKAWA Satoshi
    • 依托单位:
    Molecular mechanisms of lymphangiogenesis in cutaneous neoplasms
    • 批准号:
      20013032
    • 项目类别:
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    • 资助金额:
      $11.52万
    • 财政年份:
      2008
    • 负责人:
      HIRAKAWA Satoshi
    • 依托单位:
    海外基金