Development of a monitoring system of in vivo cell dynamics for therapeutic evaluation of psychiatric disorders

开发用于精神疾病治疗评估的体内细胞动力学监测系统

• 批准号: 23659562
• 负责人: OUCHI Yasuomi
• 金额: $ 2.33万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659562/
• 关键词: 臨床精神分子遺伝学; 神経幹細胞

It has been reported that neural stem cells are variously changed in the process of not only normal neural growth but also neuronal degeneration occurring in neuropsychiatric disorders. Despite these findings, there was no study about the contribution of neural stem cells to the physiological and pathophysiological significance. Hence we tried to develop an in vivo monitoring system with which the dynamics of the stem cells can be visualized. Using positron emission tomography with a new gene-reporter system and amino acid transporter, we were able to make a new in vivo system for measuring live neural stem cells in vivo specifically.

有报道称，神经干细胞不仅在神经正常生长的过程中，而且在神经精神障碍的神经元变性过程中也会发生不同程度的变化。尽管有这些发现，但还没有关于神经干细胞在生理和病理生理学意义上的贡献的研究。因此，我们试图开发一种体内监测系统，利用该系统可以可视化干细胞的动态。利用正电子发射断层扫描技术，结合新型基因报告系统和氨基酸转运蛋白，我们建立了一种新的活体神经干细胞体内特异性检测系统。

项目成果

NG2 細胞のCD44 を分子標的とする分子イメージング技術の創出と、その多発性硬化症治療への応用

创建针对NG2细胞中CD44的分子成像技术及其在多发性硬化症治疗中的应用

• 发表时间: 2012
• 作者: Yasuomi Ouchi;Tatsuhiro Terada;Yumi Oboshi;Etsuji Yoshikawa;Masami Futatsubashi;Toshihiko Kanno;Mikako Ogawa;Yasuhiro Magata.;Ozaki N;植木孝俊
• 通讯作者: 植木孝俊

The role of α4β2 nicotinic acetylcholine system in aging and Alzheimer's disease.

α4β2烟碱乙酰胆碱系统在衰老和阿尔茨海默病中的作用。

• 发表时间: 2013
• 作者: Yasuomi Ouchi;Tatsuhiro Terada;Yumi Oboshi;Etsuji Yoshikawa;Masami Futatsubashi;Toshihiko Kanno;Mikako Ogawa;Yasuhiro Magata.
• 通讯作者: Yasuhiro Magata.

Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders.

• DOI: 10.1001/archgenpsychiatry.2011.4
• 发表时间: 2011-03
• 期刊: Archives of general psychiatry
• 作者: Katsuaki Suzuki;G. Sugihara;Y. Ouchi;Kazuhiko Nakamura;M. Tsujii;M. Futatsubashi;Y. Iwata;K. Tsuchiya;Kaori Matsumoto;K. Takebayashi;Tomoyasu Wakuda;Y. Yoshihara;Shiro Suda;M. Kikuchi;N. Takei;Toshiro Sugiyama;T. Irie;N. Mori

SPG3A-linked hereditary spastic paraplegia associated with cerebral glucose hypometabolism.

SPG3A 相关的遗传性痉挛性截瘫与脑葡萄糖代谢低下有关。

• DOI: 10.1007/s12149-012-0673-5
• 发表时间: 2013
• 期刊: Ann Nucl Med
• 影响因子: 2.6
• 作者: Terada T;Kono S;Ouchi Y;Yoshida K;Hamaya Y;Kanaoka S;Miyajima H
• 通讯作者: Miyajima H

In vivo imaging of neuroinflammation using a new PET tracer [11C]-DPA713

使用新型 PET 示踪剂 [11C]-DPA713 进行神经炎症体内成像

• 发表时间: 2013
• 作者: Shimizu M;Shirakami Y;Hanai T;Imai K;Suetsugu A;Takai K;Shiraki M;Moriwaki H.;林由美他;横倉正倫
• 通讯作者: 横倉正倫