Gene expression studies in delayed carbon monoxide encephalopathy rat model.

迟发性一氧化碳脑病大鼠模型的基因表达研究。

• 批准号: 23659567
• 负责人: UENO Shuichi
• 金额: $ 2.33万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659567/
• 关键词: 一酸化炭素; 遅発性神経細胞障害; ラット; 受動的回避試験; DNA チップ; DNAチップ; 動物モデル; 遺伝子発現

Delayed carbon monoxide encephalopathy is a serious organic brain disorder but its mechanism is not known yet. In this study, we made the delayed carbon monoxide encephalopathy rat model and analyzed the behavior with passive avoidance test and gene expressions with DNA chip. The latencies in passive-avoidance test were significantly shorter two weeks after carbon monoxide treatment. However, there were no gene expressional changes in the hippocampus three weeks after treatment. Further studies should be needed to clarify it.

迟发性一氧化碳脑病是一种严重的器质性脑病，其发病机制尚不清楚。在本研究中，我们制作了迟发性一氧化碳脑病大鼠模型，并用被动回避实验和DNA芯片对其行为和基因表达进行了分析。一氧化碳治疗后两周，被动回避反应潜伏期明显缩短。然而，治疗三周后，海马区的基因表达没有变化。需要进一步的研究来澄清这一点。

项目成果

Distribution of D- 3- amino isobutyrate-pyruvate aminotransferase in rat brain

D-3-氨基异丁酸丙酮酸转氨酶在大鼠脑内的分布

• 发表时间: 2012
• 作者: M. Abe;S. Ochi;Y. Mori;Y Yoshino;T. Ishimaru;S. Matsuda;S. Ueno
• 通讯作者: S. Ueno

幻覚と妄想

幻觉和妄想

• 发表时间: 2011
• 作者: 福原竜治;上野修一
• 通讯作者: 上野修一

Different actions for acute and chronic administration of mirtazapine on serotonergic transmission associated with raphe nuclei and their innervation cortical regions

米氮平急性和慢性给药对中缝核及其神经支配皮质区相关血清素传递的不同作用

• 发表时间: 2011
• 期刊: Neuropharmacology
• 影响因子: 4.7
• 作者: Yamamura S;et al
• 通讯作者: et al

Relationship between sleep insufficiency and behavioral/ emotional problems

睡眠不足与行为/情绪问题之间的关系

• 发表时间: 2012
• 作者: 平田真一;久崎孝浩;西大地;池田学;Horiuchi F et al.
• 通讯作者: Horiuchi F et al.

Heteroplasmic m.1624C>T mutation of the mitochondrial tRNAVal gene in a proband and his mother with repeated consciousness disturbances

反复意识障碍的先证者及其母亲线粒体tRNAVal基因的异质性m.1624C>T突变

• 发表时间: 2012
• 期刊: Mitochondrion
• 影响因子: 4.4
• 作者: Y. Sangatsuda;M. Nakamura;A. Tomiyasu;A. Deguchi;Y. Toyota;Y. Goto;I. Nishino;S. Ueno;A. Sano
• 通讯作者: A. Sano