Study on volatile organic compounds associated with schizophrenia.

我们发现了一例精神分裂症患者，他有多个患病个体的家系，并且有移码突变，乙二醛-1基因中的酶活性降低了50%。本病例提示精神分裂症的病理生理学机制可能与羰基应激有关，46.7%的患者血浆AGEs水平较高。我们研究了与精神分裂症相关的挥发性有机化合物，以揭示疾病的病理生理学(Arai等人。《新一代精神病学》2010年版)。我们用气相色谱-质谱仪检测了病房空气中的挥发性有机化合物

We found a case with schizophrenia who is in pedigree with multiple affected individuals and had a frameshift mutation reducing enzymatic activity by 50% in glyoxalase1 gene. The case suggested possibility of carbonyl stress is involved in pathophysiology of schizophrenia and high plasma AGEs was detected in 46.7% of the patients. We studied on volatile organic compounds associated with schizophrenia to reveal pathophysiology of the disease(Arai et al. Arch Gen Psychiatry 2010). We detected volatile organic compounds contained in the air of the ward by using GCMS