Elucidation of the rupture mechanism By immunohistological analysis and computed fluid dynamics analysis according to the aneurysmal wall proparties in human ruptured cerebral aneurysm.

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Aneurysmal specimens in human clinical cases totaled 54 (ruptured 40, non-ruptured 14), which were obtained after clipping surgery, were acquired till now. As findings to be characteristic of ruptured cerebral aneurysm, <1> fibrin deposition under aneurysm endothelium, <2> infiltration of inflammatory cell to intima, <3> layered thrombus formation in inside wall surface were found.On the other hand, by immunohistological study and scanning electron microscopic study, endothelial cell seems to be still present in an aneurysm inside wall while a function falls. But, especially in ruptured aneurysm, it is speculated that its configuration and alignment was distracted, or it had been lost. When it considers from these findings, aneurysm may rupture because wall disintegration gets up by thrombus formation in intima and intramural bleeding and drastic inflammatory reaction following the endothelium disorder that was influenced by mechanical stress.