The role of Syndecan4 in the development of rheumatoid arthritis

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In this study, to try to understand the role of Syndecan4 in the development of Rheumatoid Arthritis (RA), we have compared Syn4-deficient (Syn4 KO) mice and wild-type (WT) mice in collagen-induced arthritis (CIA) model. Syn4 KO mice revealed attenuated clinical severity and pathological features in CIA model. Syn4 was mainly expressed on B cells in the draining LN (dLN), and interestingly, Syn4 KO mice showed the drastic hypoplasia of germinal center formation in the dLN. And the numbers of B cell subsets that involve in germinal center formation in the dLN, were also decreased in Syn4 KO mice. In addition, Syn4 KO mice showed reduced production of type-II collagen-specific IgG antibodies (total IgG, IgG2a and IgG2b) compared with WT mice.Our results indicated that Syn4 on B cells possibly regulates the development of RA by modulating germinal center formation and antibody production.