Design and synthesis of artificial receptors for disease-related oligosaccharides, and their applications for controlling cell functions

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Small molecules, which selectively bind to and effectively photodegrade target disease-related oligosaccharides under mild conditions, were designed and synthesized. It was found that synthesized anthraquinone(AQ)-or fullerene-boronic acid hybrids selectively bound to and photodegraded.-D-galactofuranoside, which is a sugar component of mycobacterial cell wall. In addition, it was found that photodegradation of the target oligosaccharides on the bacterial cell wall by AQ-boronic acid hybrid took place and induced significant whole-cell destruction. Furthermore, several molecules that bind to sialic acid were designed and synthesized. The results obtained from this study will contribute to the molecular design of photodegrading agents for cancer-related oligosaccharides.