Development of a sophisticated dental implant based on biomimetic engineering

基于仿生工程的复杂牙种植体的开发

• 批准号: 23659910
• 负责人: SHIMAUCHI Hidetoshi
• 金额: $ 2.25万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659910/
• 关键词: 歯科インプラント; 生体模倣(biomimetics); スキャフォールド; 生体模倣; デンタルインプラント; チタン表面処理; ハニカムフィルム

This study was aimed to develop the new fabrication method that can fabricate an ideal surface structure on implant fixture to control the microscopic surface topography suitable for osseointegration and bone regeneration. For this purpose, we used “micro-dimple imprint method" by applying honeycomb films. We fabricated the regularly arrayed micro-dimple structure on the mirror-like finished surface of Type 1 Ti plate masked with honeycomb film by wet-etching. After the etching, we obtained the regularly arrayed dimples on Ti surface with identical diameter and pitch as a honeycomb mesh structure of the mask. Human periodontal ligament (hPDL) or STRO-1^+dental follicle (STRO-1^+DF) cells were seeded and culture on the honeycomb-fabricated and control Ti. hPDL/ STRO-1^+DF cells showed stimulated proliferation and a unique forms on the fabricated Ti, that is completely different from the uniformed pattern of cell behavior on control Ti surface, suggesting that our newly developed micro-dimple imprint method is useful for the processing of implant fixture surface and fabrication the surface topography at a μm order.

本研究旨在开发一种新的制造方法，可以在种植体固定装置上制造出理想的表面结构，以控制适合骨整合和骨再生的微观表面形貌。为此，我们使用了“微凹压印法”，通过施加蜂窝薄膜。采用湿法腐蚀方法在1型钛板的镜面加工表面制备了规则排列的微坑结构。腐蚀后，我们在钛表面获得了具有相同直径和间距的规则排列的凹坑，作为掩模的蜂窝状网状结构。将人牙周膜（hPDL）或STRO-1^+牙囊（STRO-1^+DF）细胞接种并培养在蜂窝状结构和对照Ti上。hPDL/ STRO-1^+DF细胞在制备的钛表面上表现出刺激的增殖和独特的形态，这与对照钛表面上细胞行为的均匀模式完全不同，这表明我们新开发的微凹压印方法可用于种植体夹具表面的处理和微米级表面形貌的制备。

项目成果

development of 20mm micro-pored full titanium membrane for bone augmentation

开发20mm微孔全钛膜用于骨增量

• 发表时间: 2012
• 作者: Ishihata H;Nagamine M;Yoshikawa K;Sasaki K;Shimauchi H
• 通讯作者: Shimauchi H

機械と工具、チタンのマイクロピアス加工―再生医療をリードするものづくり―

机器、工具和钛微穿孔 - 引领再生医学的制造 -

• 发表时间: 2011
• 作者: 石幡浩志;長峰 勝;島内英俊
• 通讯作者: 島内英俊

歯周組織再生-医療としての現状と課題

牙周组织再生——医学治疗的现状和挑战

• 发表时间: 2012
• 作者: Nakano K;Ooshima T;島内英俊
• 通讯作者: 島内英俊

Development of 20 um Micro-pored Full-Titanium Membrane for Bone Argumentation

开发用于骨论证的20微米微孔全钛膜

• 发表时间: 2012
• 作者: Hiroshi ISHIHATA;Hiroyuki KANEKO;Mitsuru SHIMONISHI;Masashi KOMATSU
• 通讯作者: Masashi KOMATSU

Micro-pierce Fabricated Titanium Mesh as a New Cell-Interactive Barrier Membrane

微穿孔制造钛网作为新型细胞相互作用屏障膜

• 发表时间: 2012
• 作者: SHIMAUCHI H;ISHIHATA H;YOSHIKAWA K;NAGAMINE M;OHMORI H;KOMATSU M;SASAKI K
• 通讯作者: SASAKI K