Enhancement of bone health in rat mandible by application of mechanical stimulation using a mouthpiece-like vibrator

本研究的目的是开发一种新的方法来提高下颌骨强度的低幅度，高频率的机械振动，通过一个嘴型振动器的应用。虽然大鼠门牙被固定到咬嘴，并暴露于振动，共振点，这是预期最大限度地提高振动的效果，没有观察到。然而，在几十赫兹的几十到几百微米的振幅的振动可以增强大鼠下颌骨的质量传输，体外骨细胞的NO分泌，以及大鼠切牙拔牙窝的骨愈合。

The aim of this study was to develop a new method to enhance the strength of mandibles by an application of low-magnitude, high-frequency mechanical vibration through a mouthpiece-type vibrator. Although rat incisors were fixed to the mouthpiece and exposed to the vibration, the resonance point, which was expected to maximize the effect of the vibration, was not observed. However, the vibration with amplitudes of several tens to hundreds microns at several tens of hertz could enhance mass transport in rat mandibles, NO secretion from osteocytes in vitro, and bone healing of rat incisor extraction sockets.