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Development of immunotherapy against the bone destructive tumor

Development of immunotherapy against the bone destructive tumor
针对骨破坏性肿瘤的免疫疗法的发展
批准号:
23659946
负责人:
HIASA Masahiro
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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项目成果

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中文摘要
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英文摘要
Multiple myeloma (MM) generates devastating bone destruction. We recently reported that TNFα converting enzyme (TACE) expression in monocytes cleaved their surface M-CSF receptor (M-CSFR), which drastically disrupts osteoclastogenesis(Blood, 2009). Because TACE activity is inhibited by TIMP3, we explored the role of BMSC-derived TIMP3 in monocytic differentiation into DC or OC in MM. This study clarified that TIMP3 over-produced in MM bone marrow microenvironment restores surface M-CSFR on monocytes to facilitate their downstream signaling, which causes extensive bone destruction and impaired DC differentiation in MM. TIMP3 may therefore become a novel target in the treatment of MM bone disease.
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会议论文
Pimキナーゼの阻害は骨芽細胞分化を促進し、骨髄腫骨病変の形成と腫瘍進展を抑制する
抑制 Pim 激酶可促进成骨细胞分化并抑制骨髓瘤骨病变形成和肿瘤进展
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Nishikawa, Y., 日浅雅博]
通讯作者: 日浅雅博
Dual effects of Pim inhibition on myeloma: induction of bone formation and tumor suppression
Pim 抑制对骨髓瘤的双重作用:诱导骨形成和抑制肿瘤
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [山本直典, 藤田祐生, 加藤逸郎, 中澤光博, 岩井聡一, 由良義明, Masahiro Hiasa]
通讯作者: Masahiro Hiasa
DOI: 10.1007/s12185-011-0850-7
发表时间: 2011-04
期刊: International Journal of Hematology
影响因子: 2.1
作者: [A. Nakano;M. Abe;Asuka Oda;Hiroe Amou;M. Hiasa;S. Nakamura;H. Miki;T. Harada;S. Fujii;K. Kagawa;K. Takeuchi;Takashi Watanabe;S. Ozaki;Toshio Matsumoto]
通讯作者: A. Nakano;M. Abe;Asuka Oda;Hiroe Amou;M. Hiasa;S. Nakamura;H. Miki;T. Harada;S. Fujii;K. Kagawa;K. Takeuchi;Takashi Watanabe;S. Ozaki;Toshio Matsumoto
Pimキナーゼの阻4害は骨芽細胞分化を促進し、骨髄腫骨病変の形成と腫瘍進展を抑制する
抑制 Pim 激酶可促进成骨细胞分化并抑制骨髓瘤骨病变形成和肿瘤进展。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [濱田正和, 岩井聡一, 米川敦子, 森田祥弘, 由良義明, 日浅雅博]
通讯作者: 日浅雅博
12
    Elucidation of molecular mechanisms of cancer progression by mechanical unloading
    • 批准号:
      19K22719
    • 项目类别:
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额:
      $4.16万
    • 财政年份:
      2019
    • 负责人:
      HIASA Masahiro
    • 依托单位:
    Elucidation of the pathogenesis of bone diseases mediated by osteocyte-sensory nerve networks
    • 批准号:
      17H05104
    • 项目类别:
      Grant-in-Aid for Young Scientists (A)
    • 资助金额:
      $16.22万
    • 财政年份:
      2017
    • 负责人:
      HIASA Masahiro
    • 依托单位:
    Clarification of the function of TIMP3 in fracture healing and development of new fracture healing drug
    • 批准号:
      21792077
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.75万
    • 财政年份:
      2009
    • 负责人:
      HIASA Masahiro
    • 依托单位:
    海外基金