Development of immunotherapy against the bone destructive tumor
Development of immunotherapy against the bone destructive tumor
批准号:
23659946
负责人:
HIASA Masahiro
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
多发性骨髓瘤(MM)会对骨骼造成毁灭性的破坏。我们最近报道了单核细胞中TNFα转换酶(TACE)的表达会破坏其表面M-CSF受体(M-CSFR),从而严重破坏破骨细胞的形成(Blood, 2009)。由于TACE活性被TIMP3抑制,我们探索了骨髓间充质干细胞来源的TIMP3在MM单核细胞分化为DC或OC中的作用。本研究阐明了MM骨髓微环境中过量产生的TIMP3恢复单核细胞表面M-CSFR,促进其下游信号传导,从而导致MM广泛的骨破坏和DC分化受损。因此TIMP3可能成为MM骨病治疗的新靶点。
英文摘要
Multiple myeloma (MM) generates devastating bone destruction. We recently reported that TNFα converting enzyme (TACE) expression in monocytes cleaved their surface M-CSF receptor (M-CSFR), which drastically disrupts osteoclastogenesis(Blood, 2009). Because TACE activity is inhibited by TIMP3, we explored the role of BMSC-derived TIMP3 in monocytic differentiation into DC or OC in MM. This study clarified that TIMP3 over-produced in MM bone marrow microenvironment restores surface M-CSFR on monocytes to facilitate their downstream signaling, which causes extensive bone destruction and impaired DC differentiation in MM. TIMP3 may therefore become a novel target in the treatment of MM bone disease.
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Pimキナーゼの阻害は骨芽細胞分化を促進し、骨髄腫骨病変の形成と腫瘍進展を抑制する
抑制 Pim 激酶可促进成骨细胞分化并抑制骨髓瘤骨病变形成和肿瘤进展
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nishikawa, Y., 日浅雅博]
通讯作者:
日浅雅博
Dual effects of Pim inhibition on myeloma: induction of bone formation and tumor suppression
Pim 抑制对骨髓瘤的双重作用:诱导骨形成和抑制肿瘤
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[山本直典, 藤田祐生, 加藤逸郎, 中澤光博, 岩井聡一, 由良義明, Masahiro Hiasa]
通讯作者:
Masahiro Hiasa
DOI:
10.1007/s12185-011-0850-7
发表时间:
2011-04
期刊:
International Journal of Hematology
影响因子:
2.1
作者:
[A. Nakano;M. Abe;Asuka Oda;Hiroe Amou;M. Hiasa;S. Nakamura;H. Miki;T. Harada;S. Fujii;K. Kagawa;K. Takeuchi;Takashi Watanabe;S. Ozaki;Toshio Matsumoto]
通讯作者:
A. Nakano;M. Abe;Asuka Oda;Hiroe Amou;M. Hiasa;S. Nakamura;H. Miki;T. Harada;S. Fujii;K. Kagawa;K. Takeuchi;Takashi Watanabe;S. Ozaki;Toshio Matsumoto
Pimキナーゼの阻4害は骨芽細胞分化を促進し、骨髄腫骨病変の形成と腫瘍進展を抑制する
抑制 Pim 激酶可促进成骨细胞分化并抑制骨髓瘤骨病变形成和肿瘤进展。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[濱田正和, 岩井聡一, 米川敦子, 森田祥弘, 由良義明, 日浅雅博]
通讯作者:
日浅雅博
DOI:
10.1038/leu.2011.60
发表时间:
2011-07-01
期刊:
LEUKEMIA
影响因子:
11.4
作者:
[Asano, J., Nakano, A., Abe, M.]
通讯作者:
Abe, M.
共 12 条
Elucidation of molecular mechanisms of cancer progression by mechanical unloading
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批准号:19K22719
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.16万
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财政年份:2019
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负责人:HIASA Masahiro
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依托单位:
Elucidation of the pathogenesis of bone diseases mediated by osteocyte-sensory nerve networks
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批准号:17H05104
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$16.22万
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财政年份:2017
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负责人:HIASA Masahiro
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依托单位:
Clarification of the function of TIMP3 in fracture healing and development of new fracture healing drug
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批准号:21792077
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2009
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负责人:HIASA Masahiro
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依托单位:
海外基金