The novel periodontal regeneration therapy optimized for tissue engineered cell culture treatment by using the full metal barrier

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In order to improve the physical property of the current model of the barrier membrane, the new style of the barrier membrane has implemented by using microfabrication technology to create high-density form of 20 μm pored pure titanium membrane. It has a significant advantage on the toughness and durability to stabilized a tissue regeneration space to contribute establish to reproduce the target tissue, and also on the prevention of a contamination by oral microorganisms. The new titanium membrane is relatively saved a thickness that eliminated a tissue regeneration volume to be compromised the space in comparison with the one of the current models of barrier membrane. membrane.On the culture test by using human periodontal ligament-derived cells, the new titanium membrane showed excellent properties supporting cell attachment, migration and proliferation to be promising the periodontal tissue regeneration successfully. Its usefulness has been confirmed in the animal test using beagle dogs.