The novel periodontal regeneration therapy optimized for tissue engineered cell culture treatment by using the full metal barrier

通过使用全金属屏障，针对组织工程细胞培养治疗进行优化的新型牙周再生疗法

• 批准号: 23659973
• 负责人: ISHIHATA Hiroshi
• 金额: $ 2.25万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659973/
• 关键词: チタン; バリアメンブレン; 歯周組織再生; マイクロメッシュ; バイオミメティックス; 純チタン; スキャフォールド; GBR; チタンメンブレン; レーザー; 再生医療; チタンメッシュ; スペースメイキング; 口蓋裂; 眼窩下破裂骨折

In order to improve the physical property of the current model of the barrier membrane, the new style of the barrier membrane has implemented by using microfabrication technology to create high-density form of 20 μm pored pure titanium membrane. It has a significant advantage on the toughness and durability to stabilized a tissue regeneration space to contribute establish to reproduce the target tissue, and also on the prevention of a contamination by oral microorganisms. The new titanium membrane is relatively saved a thickness that eliminated a tissue regeneration volume to be compromised the space in comparison with the one of the current models of barrier membrane. membrane.On the culture test by using human periodontal ligament-derived cells, the new titanium membrane showed excellent properties supporting cell attachment, migration and proliferation to be promising the periodontal tissue regeneration successfully. Its usefulness has been confirmed in the animal test using beagle dogs.

为了改善现有阻隔膜模型的物理性能，采用微细加工技术制造出高密度的20 μm多孔纯钛膜，实现了新型阻隔膜的研制。其在稳定组织再生空间以有助于建立再生目标组织的韧性和耐久性方面以及在防止口腔微生物污染方面具有显著的优点。新型钛膜与目前的屏障膜相比，相对节省了一个厚度，消除了组织再生体积受到损害的空间。在人牙周膜衍生细胞的培养试验中，新型钛膜显示出良好的支持细胞附着、迁移和增殖的性能，有望成功地用于牙周组织再生。其有效性已在使用比格犬的动物试验中得到证实。

项目成果

Effects of applying glutaraldehyde-containing desensitizer formulations on reducing dentin

应用含戊二醛脱敏剂制剂对牙本质还原的影响

• 发表时间: 2012
• 期刊: Journal of Dental Sciences
• 影响因子: 3.5
• 作者: Ishihata;H.*;Kanehira;M.;Finger;W.J.;Shimauchi;H. and Komatsu;M.
• 通讯作者: M.

In vitro dentin permeability after application of Gluma[○!R] desensitizer as aqueous solution or aqueous fumed silica dispersion

使用 Gluma[○!R] 脱敏剂水溶液或气相二氧化硅水分散体后的体外牙本质渗透性

• DOI: 10.1590/s1678-77572004000300002
• 发表时间: 2011
• 期刊: Journal of Applied Oral Science
• 影响因子: 2.7
• 作者: Ishihata H;Finger WJ;Kanehira M;Shimauchi H;Komatsu M
• 通讯作者: Komatsu M

Application of honeycomb patterned porous films as functional scaffold for periodontal regenerative therapy

蜂窝状多孔膜作为功能支架在牙周再生治疗中的应用

• 发表时间: 2012
• 作者: Nagayoshi Iwama;Hiroshi Ishihata;Takahito Kawano;Hidetoshi Shimauchi;Masatsugu Shimomura
• 通讯作者: Masatsugu Shimomura

Development of 20 um Micro-pored Full-Titanium Membrane for Bone Argumentation

开发用于骨论证的20微米微孔全钛膜

• 发表时间: 2012
• 作者: Hiroshi ISHIHATA;Hiroyuki KANEKO;Mitsuru SHIMONISHI;Masashi KOMATSU
• 通讯作者: Masashi KOMATSU

医療用多孔プレート

医用多孔板

• 发表时间: 2012