Investigation for "intracellular obesity hypothesis" and its clinical application

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We investigated the cause of metabolic disorders in non-obese subjects, frequently seen in Asian people. We recruited 85 non-obese subjects and obese subjects with metabolic syndrome (n=14). We measured intramyocellular lipid (IMCL) and intrahepatic lipid (IHL). We also evaluated insulin sensitivity in muscle and liver by glucose clamp with stable isotope. Muscle insulin resistance was associated with higher TG and IHL and lower HDL-C levels. Multiple regression analysis revealed that maximum oxygen uptake, visceral fat volume and physical activity levels are recognized as independent determinant of muscle IR. In non-obese subjects, IRs in muscle and liver are independently occurred and physical activity may be important determinant of muscle IR.