Regulation of circadian clock by DNA damage stress

生物钟是内在的时间跟踪系统，赋予生物体生存优势。对动物模型和人类肿瘤样本的研究表明，昼夜节律的破坏是导致哺乳动物癌症发展的一个重要内源性因素。生物钟机制的核心是分子钟，这是一个细胞自主和自我维持的振荡器系统。这项研究试图确定分子时钟和DNA损伤反应之间的分子联系，并发现应激激酶丝裂原激活的蛋白激酶7是哺乳动物细胞中分子时钟的调节者。

Circadian clocks are intrinsic, time-tracking systems that endow organisms with a survival advantage. Studies of animal models and human tumor samples have revealed that the disruption of circadian rhythms is an important endogenous factor that can contribute to mammalian cancer development. The core of the circadian clock mechanism is molecular clock, a cell-autonomous and self-sustained oscillator system. This study tried to identify a molecular link between the molecular clock and DNA damage responses and have found that the stress kinase mitogen-activated protein kinase kinase 7 is a regulator of the molecular clock in mammalian cells.