Role of circadian regulator BMAL1 in chromatin remodeling

昼夜节律调节剂 BMAL1 在染色质重塑中的作用

• 批准号: 23657085
• 负责人: HIRAYAMA Jun
• 金额: $ 2.58万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23657085/
• 关键词: 概日リズム; DAXX; クロマチン; BMAL1,ヒストン; シャペロン; 時計蛋白質; BMAL1; ヒストン

Chromatin, the nucleoprotein structure into which the eukaryotic genome is organized, enables essential biological processes such as regulation of transcription. A variety of remodeling events enable the architecture of chromatin to transition between a condensed and a decondensed state, each state being coupled to specific cellular functions. The covalent modifications occur on the N-terminal tails of the core histones H2A, H2B, H3 and H4. Several histone modifications contribute to chromatin remodeling and thereby to the control of a large array of nuclear processes. In addition, the disposition of the tails renders these domains accessible to modifications that could reversibly modulate chromatin structure. Although the death domain-associated protein DAXX has traditionally been associated with the regulation of cell death pathways, recent studies have demonstrated that DAXX can function as a histone chaperone.Circadian clocks are intrinsic, time-tracking systems that endow organisms with a survival advantage. In mammals, the transcription factors, BMAL1, is an essential circadian regulator. I have identified BMAL1 as a novel DAXX-interacting protein. This study provides several lines of evidence indicating that DAXX-BMAL1 interaction may have important roles in dynamic changes in chromatin transitions.

染色质是真核生物基因组组成的核蛋白结构，能够进行重要的生物学过程，如转录调控。各种重塑事件使得染色质的结构能够在凝聚状态和解凝聚状态之间转变，每种状态与特定的细胞功能偶联。共价修饰发生在核心组蛋白H2 A、H2 B、H3和H4的N-末端尾部。一些组蛋白修饰有助于染色质重塑，从而控制大量的核过程。此外，尾部的布置使得这些结构域可被可可逆地调节染色质结构的修饰所接近。虽然死亡结构域相关蛋白DAXX传统上与细胞死亡途径的调节有关，但最近的研究表明DAXX可以作为组蛋白伴侣发挥作用。生物钟是赋予生物体生存优势的内在时间跟踪系统。在哺乳动物中，转录因子BMAL 1是一种重要的昼夜节律调节因子。我已经确定BMAL 1是一种新型的DAXX相互作用蛋白。这项研究提供了几条证据，表明DAXX-BMAL 1相互作用可能在染色质转换的动态变化中发挥重要作用。

项目成果

PER2 controls lipid metabolism by direct regulation of PPARγ.

• DOI: 10.1016/j.cmet.2010.10.005
• 发表时间: 2010-11-03
• 期刊: Cell metabolism
• 影响因子: 29
• 作者: Grimaldi B;Bellet MM;Katada S;Astarita G;Hirayama J;Amin RH;Granneman JG;Piomelli D;Leff T;Sassone-Corsi P
• 通讯作者: Sassone-Corsi P

Involvement of the stress kinase Mitogen-activated Protein Kinase Kinase 7 in the regulation of mammalian circadian clock

应激激酶丝裂原激活蛋白激酶 7 参与哺乳动物生物钟的调节

• 发表时间: 2012
• 期刊: J. Biol. Chem.
• 作者: Uchida Y;Osaki T;Yamasaki T;Shimomura T;Hata S;Horikawa K;Shibata S;Todo T;Hirayama J;and Nishina H.
• 通讯作者: and Nishina H.

Light-dependent transcription of circadian clock

生物钟的光依赖性转录

• 发表时间: 2011
• 作者: 米村洋而;二井勇人;柳下聡介;周防諭;石浦章一;劉 暁輝・巣山慶太郎・松島綾美・野瀬 健・下東康幸;Hirayama J
• 通讯作者: Hirayama J

Involvement of the Stress Kinase Mitogen-activated Protein Kinase Kinase 7 in the Regulation of the Mammalian Circadian Clock

应激激酶丝裂原激活蛋白激酶激酶 7 参与哺乳动物昼夜节律的调节

• 发表时间: 2012
• 期刊: J. Biol. Chem
• 作者: Yoshimi Uchida;Tomomi Osaki;Tokiwa Yamasaki;Tadanori Shimomura;Shoji Hata;Kazumasa Horikawa;Shigenobu Shibata;Takeshi Todo;Jun Hirayama and Hiroshi Nishina
• 通讯作者: Jun Hirayama and Hiroshi Nishina

Light-dependent regulation of zebrafish circadian transcription

斑马鱼昼夜节律转录的光依赖性调节

• 发表时间: 2011
• 作者: Hirayama J;Osaki Tomomi;Nishina H
• 通讯作者: Nishina H