Development of fuzzy olfaction system based on DNA-functionalized highly sensitive piezoresistive membrane-type sensor

基于DNA功能化高灵敏压阻膜式传感器的模糊嗅觉系统的研制

• 批准号: 23685017
• 负责人: YOSHIKAWA Genki
• 金额: $ 17.97万
• 依托单位: National Institute for Materials Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23685017/
• 关键词: 嗅覚センサー; ナノメカニカルセンサー; MSS; マイクロ・ナノデバイス; ナノバイオ; 自己検知

To realize an olfaction sensor based on a piezoresistive nanomechanical membrane-type surface stress sensor (MSS), comprehensive optimization was performed on a sensing element, a coating method of a receptor layer, and a measurement system. A sensor chip having a two dimensional array with more than 100 times higher sensitivity compared to a conventional sensor was designed and fabricated. For the coating method, the double-side coating which is compatible with standard protocols was established. This allows anybody to perform coating procedure without any specialized device or technique. It also significantly improved the reproducibility and quality of coating layers. Moreover, a compact USB-powered/operated system was developed, and the real-time identification of smells was demonstrated. Furthermore, the cancer diagnostics through breath analysis was successfully performed, demonstrating the high potential of the olfaction sensor based on the MSS platform.

为了实现基于压阻式纳米机械膜式表面应力传感器（MSS）的嗅觉传感器，对传感元件、感受层的涂覆方法和测量系统进行了综合优化。设计并制造了具有二维阵列的传感器芯片，其灵敏度比传统传感器高100倍以上。对于涂层方法，建立了与标准方案兼容的双面涂层。这使得任何人都可以在没有任何专门设备或技术的情况下执行涂层程序。它还显著提高了涂层的再现性和质量。此外，一个紧凑的USB供电/操作系统的开发，并展示了实时识别的气味。此外，通过呼吸分析成功地进行了癌症诊断，证明了基于MSS平台的嗅觉传感器的高潜力。

项目成果

Effects of coating materials on two dimensional stress-induced deflection of nanomechanical sensors.

涂层材料对纳米机械传感器二维应力引起的偏转的影响。

• DOI: 10.1166/jnn.2014.8604
• 发表时间: 2014
• 期刊: Journal of nanoscience and nanotechnology
• 作者: Genki Yoshikawa;Cory J Y Lee;Kota Shiba
• 通讯作者: Kota Shiba

New sensors for rapid identification of pathogenic bacteria

用于快速识别病原菌的新型传感器

• 发表时间: 2012
• 作者: Kotaro Satoh;and Masami Kamigaito;Genki Yoshikawa
• 通讯作者: Genki Yoshikawa

2D-Array of Nanomechanical Membrane-type Surface Stress Sensor (MSS), and Double-side Coating for Easier Fabrication of Various Receptor Layers

纳米机械膜型表面应力传感器 (MSS) 的二维阵列和双面涂层可更轻松地制造各种受体层

• 发表时间: 2012
• 作者: G. Yoshikawa;T. Akiyama;F. Loizeau;S. Gautsch;M. Palumbo;T. Nakayama;P. Vettiger;N. F. d. Rooij;and M. Aono
• 通讯作者: and M. Aono

Optimization of piezoresistive cantilever sensors towards highly sensitive membrane-type surface stress sensor (MSS) for medical, security, and environmental applications

针对医疗、安全和环境应用的高灵敏度膜型表面应力传感器 (MSS) 优化压阻悬臂梁传感器

• 发表时间: 2011
• 作者: 大内 誠，澤本 光男;後藤淳;Genki Yoshikawa
• 通讯作者: Genki Yoshikawa

Highly sensitive membrane-type surface stress sensor (MSS) and its applications

高灵敏薄膜式表面应力传感器（MSS）及其应用

• 发表时间: 2011
• 作者: Genki Yoshikawa;Terunobu Akiyama;Sebastian Gautsch;Peter Vettiger;Heinrich Rohrer
• 通讯作者: Heinrich Rohrer