Development of fuzzy olfaction system based on DNA-functionalized highly sensitive piezoresistive membrane-type sensor

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To realize an olfaction sensor based on a piezoresistive nanomechanical membrane-type surface stress sensor (MSS), comprehensive optimization was performed on a sensing element, a coating method of a receptor layer, and a measurement system. A sensor chip having a two dimensional array with more than 100 times higher sensitivity compared to a conventional sensor was designed and fabricated. For the coating method, the double-side coating which is compatible with standard protocols was established. This allows anybody to perform coating procedure without any specialized device or technique. It also significantly improved the reproducibility and quality of coating layers. Moreover, a compact USB-powered/operated system was developed, and the real-time identification of smells was demonstrated. Furthermore, the cancer diagnostics through breath analysis was successfully performed, demonstrating the high potential of the olfaction sensor based on the MSS platform.